Fluorinated quinoid inhibitor: Possible 'pure' arylator predicted by the simple theoretical calculation

Seung Wook Ham, Jong In Choe, Mei Fang Wang, Vincent Peyregne, Brian I. Carr

Research output: Contribution to journalArticlepeer-review

Abstract

We report on the fluorinated form of Cpd 5 as a cell growth inhibitor. This compound is 3-fold more potent than the parent Cpd 5 and is predicted, using the semi-empirical AM1 method to be only an arylator of cysteine-containing proteins, without generating reactive oxygen species.

Original languageEnglish
Pages (from-to)4103-4105
Number of pages3
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number15
DOIs
Publication statusPublished - Aug 2 2004

Keywords

  • Cdc25 inhibitor
  • Quinones
  • Reduction potential

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery
  • Pharmaceutical Science

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