Fluoro-deoxi-glucose uptake and angiogenesis are independent biological features in lung metastases

G. Veronesi, C. Landoni, G. Pelosi, M. Picchio, A. Sonzogni, M. E. Leon, P. G. Solli, F. Leo, L. Spaggiari, M. Bellomi, F. Fazio, U. Pastorino

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Neoangiogenesis and enhanced glucose metabolism in neoplasms are likely to be activated by the same biochemical stimulus; hypoxia. A correlation between these two parameters has been postulated. The objective of this study was to evaluate the relationship between Fluoro-desoxi-glucose uptake at positron emission tomography scan and angiogenesis in lung metastasis. Fluoro-desoxi-glucose activity, expressed as a standard uptake value, and microvessel intratumoural density, were retrospectively calculated in a series of 43 lung metastasis resected in 19 patients. Primary sites were colorectal cancer in 16 metastases, sarcoma in eight, gynaecological in four and other sites in 15. The correlation between the two parameters was tested by logistic regression and multivariate analysis. Positron emission tomography scan was positive in 17 patients (sensitivity 89%). No correlation was observed between standard uptake value and microvessel intratumoural density in this series of lung metastasis. Positron emission tomography negative and positive nodules presented comparable value of microvessel intratumoural density (12.9 vs 11.3). Standard uptake value was significantly correlated with nodules size and was higher in colon cancer metastasis than in sarcoma ones. Microvessel intratumoural density was independent from nodule size but significantly higher in sarcoma than in colon cancer metastasis. The lack of correlation was confirmed by multivariate analysis after adjustment for tumour type and nodules size. The present study demonstrated that positron emission tomography scan is positive in a high proportion of patients regardless of microvessel density. Glucose uptake and angiogenesis appear to be independent biological features in lung metastasis. This observation may have implications for future antiangiogenic therapies.

Original languageEnglish
Pages (from-to)1391-1395
Number of pages5
JournalBritish Journal of Cancer
Volume86
Issue number9
DOIs
Publication statusPublished - May 6 2002

Fingerprint

Microvessels
Neoplasm Metastasis
Glucose
Lung
Positron-Emission Tomography
Desoximetasone
Sarcoma
Colonic Neoplasms
Multivariate Analysis
Colorectal Neoplasms
Neoplasms
Logistic Models
Regression Analysis
Therapeutics

Keywords

  • Angiogenesis
  • Fluoro-desoxi-glucose uptake
  • Microvessel density
  • PET
  • Secondary lung cancer

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

Cite this

Fluoro-deoxi-glucose uptake and angiogenesis are independent biological features in lung metastases. / Veronesi, G.; Landoni, C.; Pelosi, G.; Picchio, M.; Sonzogni, A.; Leon, M. E.; Solli, P. G.; Leo, F.; Spaggiari, L.; Bellomi, M.; Fazio, F.; Pastorino, U.

In: British Journal of Cancer, Vol. 86, No. 9, 06.05.2002, p. 1391-1395.

Research output: Contribution to journalArticle

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abstract = "Neoangiogenesis and enhanced glucose metabolism in neoplasms are likely to be activated by the same biochemical stimulus; hypoxia. A correlation between these two parameters has been postulated. The objective of this study was to evaluate the relationship between Fluoro-desoxi-glucose uptake at positron emission tomography scan and angiogenesis in lung metastasis. Fluoro-desoxi-glucose activity, expressed as a standard uptake value, and microvessel intratumoural density, were retrospectively calculated in a series of 43 lung metastasis resected in 19 patients. Primary sites were colorectal cancer in 16 metastases, sarcoma in eight, gynaecological in four and other sites in 15. The correlation between the two parameters was tested by logistic regression and multivariate analysis. Positron emission tomography scan was positive in 17 patients (sensitivity 89{\%}). No correlation was observed between standard uptake value and microvessel intratumoural density in this series of lung metastasis. Positron emission tomography negative and positive nodules presented comparable value of microvessel intratumoural density (12.9 vs 11.3). Standard uptake value was significantly correlated with nodules size and was higher in colon cancer metastasis than in sarcoma ones. Microvessel intratumoural density was independent from nodule size but significantly higher in sarcoma than in colon cancer metastasis. The lack of correlation was confirmed by multivariate analysis after adjustment for tumour type and nodules size. The present study demonstrated that positron emission tomography scan is positive in a high proportion of patients regardless of microvessel density. Glucose uptake and angiogenesis appear to be independent biological features in lung metastasis. This observation may have implications for future antiangiogenic therapies.",
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AU - Leon, M. E.

AU - Solli, P. G.

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