Abstract
The purpose of this study was to evaluate the efficacy and safety of five fluoroquinolones: ofloxacin, pefloxacin, ciprofloxacin, enoxacin, and norfloxacin, when compared with chloramphenicol in the therapy of typhoid fever. One hundred fifty-six patients suffering from Salmonella typhi infection entered this open study. They were divided into six groups and randomly assigned. A wide microbiologic study was conducted to support the thesis that isolates of S typhi showing identical serological and biochemical characteristics, were a single clone, as a recent genetic work has proven. At the conclusion of treatment, the enoxacin and norfloxacin groups reported some nonresponders and patients with chronic enteric carrier state. Ofloxacin and ciprofloxacin were more effective than chloramphenicol. No relapses or chronic enteric carrier states were reported in these two groups or the pefloxacin group but ofloxacin was more effective, with milder side effects.
| Original language | English |
|---|---|
| Pages (from-to) | 532-542 |
| Number of pages | 11 |
| Journal | Current Therapeutic Research |
| Volume | 52 |
| Issue number | 4 |
| DOIs | |
| Publication status | Published - 1992 |
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ASJC Scopus subject areas
- Medicine(all)
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Fluoroquinolones versus chloramphenicol in the therapy of typhoid fever : A clinical and microbiological study. / Morelli, Giuseppe; Mazzoli, Sandra; Tortoli, Enrico; Tullia Simonetti, M.; Perruna, Francesco; Postiglione, Attilio.
In: Current Therapeutic Research, Vol. 52, No. 4, 1992, p. 532-542.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Fluoroquinolones versus chloramphenicol in the therapy of typhoid fever
T2 - A clinical and microbiological study
AU - Morelli, Giuseppe
AU - Mazzoli, Sandra
AU - Tortoli, Enrico
AU - Tullia Simonetti, M.
AU - Perruna, Francesco
AU - Postiglione, Attilio
PY - 1992
Y1 - 1992
N2 - The purpose of this study was to evaluate the efficacy and safety of five fluoroquinolones: ofloxacin, pefloxacin, ciprofloxacin, enoxacin, and norfloxacin, when compared with chloramphenicol in the therapy of typhoid fever. One hundred fifty-six patients suffering from Salmonella typhi infection entered this open study. They were divided into six groups and randomly assigned. A wide microbiologic study was conducted to support the thesis that isolates of S typhi showing identical serological and biochemical characteristics, were a single clone, as a recent genetic work has proven. At the conclusion of treatment, the enoxacin and norfloxacin groups reported some nonresponders and patients with chronic enteric carrier state. Ofloxacin and ciprofloxacin were more effective than chloramphenicol. No relapses or chronic enteric carrier states were reported in these two groups or the pefloxacin group but ofloxacin was more effective, with milder side effects.
AB - The purpose of this study was to evaluate the efficacy and safety of five fluoroquinolones: ofloxacin, pefloxacin, ciprofloxacin, enoxacin, and norfloxacin, when compared with chloramphenicol in the therapy of typhoid fever. One hundred fifty-six patients suffering from Salmonella typhi infection entered this open study. They were divided into six groups and randomly assigned. A wide microbiologic study was conducted to support the thesis that isolates of S typhi showing identical serological and biochemical characteristics, were a single clone, as a recent genetic work has proven. At the conclusion of treatment, the enoxacin and norfloxacin groups reported some nonresponders and patients with chronic enteric carrier state. Ofloxacin and ciprofloxacin were more effective than chloramphenicol. No relapses or chronic enteric carrier states were reported in these two groups or the pefloxacin group but ofloxacin was more effective, with milder side effects.
UR - http://www.scopus.com/inward/record.url?scp=0026660597&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026660597&partnerID=8YFLogxK
U2 - 10.1016/S0011-393X(05)80459-X
DO - 10.1016/S0011-393X(05)80459-X
M3 - Article
AN - SCOPUS:0026660597
VL - 52
SP - 532
EP - 542
JO - Current Therapeutic Research - Clinical and Experimental
JF - Current Therapeutic Research - Clinical and Experimental
SN - 0011-393X
IS - 4
ER -