Flushing in rosacea: A possible mechanism

Marcella Guarrera, Aurora Parodi, Carla Cipriani, Carla Divano, Alfredo Rebora

Research output: Contribution to journalArticle


Flushing in rosacea has been investigated by means of (a) pharmacological inhibition of some possible chemical mediators and (b) titration of bradykinin as a possible effector directly in the blood. Clonidine-inhibited flushing was seen in all patients (mean 45%), other drugs had poorer results. Bradykinin increased in all patients at the climax of flushing (mean 60%). These findings support the hypothesis that epinephrine promotes a bradykinin release responsible for vasodilation.

Original languageEnglish
Pages (from-to)311-316
Number of pages6
JournalArchives of Dermatological Research
Issue number3-4
Publication statusPublished - Sep 1982


  • Bradykinin
  • Clonidine
  • Epinephrine
  • Flush
  • Rosacea

ASJC Scopus subject areas

  • Dermatology

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    Guarrera, M., Parodi, A., Cipriani, C., Divano, C., & Rebora, A. (1982). Flushing in rosacea: A possible mechanism. Archives of Dermatological Research, 272(3-4), 311-316. https://doi.org/10.1007/BF00509061