fMRI changes in relapsing-remitting multiple sclerosis patients complaining of fatigue after IFNβ-1a injection

Research output: Contribution to journalArticle

Abstract

If fatigue in multiple sclerosis (MS) is related to an abnormal activation of the sensorimotor brain network, the activity of such a network should vary with varying fatigue. We studied 22 patients treated with interferon beta 1a (IFNβ-1a; Avonex, Biogen, Cambridge, MA) with no fatigue (10) and with reversible fatigue (12). fMRI examinations were performed: 1) the same day of IFNβ-1a injection (no fatigue; entry), 2) the day after IFNβ-1a injection (fatigue; time 1), and 3) 4 days after IFNβ-1a injection (no fatigue; time 2). Patients performed a simple motor task with the right, clinically unaffected hand. At time 1, compared with entry and time 2, MS patients with reversible fatigue showed an increased activation of the thalamus bilaterally. In MS patients without fatigue thalamus was more activated at entry than at time 1. In both groups at entry the primary SMC and the SMA were more activated than at times 1 and 2. At entry and time 1, when compared to patients with reversible fatigue, those without showed increased activations of the SII Conversely, patients with reversible fatigue had increased activations of the thalamus and of several regions of the frontal lobes. An abnormal recruitment of the fronto-thalamic circuitry is associated with IFNβ-1a-induced fatigue in MS patients.

Original languageEnglish
Pages (from-to)373-382
Number of pages10
JournalHuman Brain Mapping
Volume28
Issue number5
DOIs
Publication statusPublished - May 2007

Keywords

  • Fatigue
  • Functional magnetic resonance imaging
  • Interferon beta-1a
  • Multiple sclerosis

ASJC Scopus subject areas

  • Clinical Neurology
  • Neuroscience(all)
  • Radiological and Ultrasound Technology

Fingerprint Dive into the research topics of 'fMRI changes in relapsing-remitting multiple sclerosis patients complaining of fatigue after IFNβ-1a injection'. Together they form a unique fingerprint.

  • Cite this