fMRI changes in the brain associated with the carotid compression test

Andrea Righini, Massimo Orsi, Carlo Sebastiano Tadeo, Giovanni Ceccarelli, Marco Locatelli, Francesco Lucchetti, Marco Leonardi, Gian Piero Cabrini

Research output: Contribution to journalArticle

Abstract

Purpose: The purpose of our investigation was to study in normal volunteers the response to a unilateral common carotid (CC) compression test using dynamic MRI sensitive to variations in blood magnetic susceptibility. Method: Nine volunteers, positioned in a 1.5 T MR scanner, performed a unilateral 40 to 45 s CC self-compression during the acquisition of single slice axial T2*-weighted FLASH images. Results: In three subjects, the signal showed a significant 2% drop from baseline in the ipsilateral frontal temporal cortex during the compression. In another three subjects, a significant 1.5-2% signal decrease was observed in both hemispheres. In two subjects whose MR angiography showed abnormalities of the circle of Willis, the bilateral signal drop was more remarkable (3%). In one volunteer, the signal did not change. Conclusion: Increased deoxyhemoglobin within the brain microcirculation is the probable explanation for the signal drop. This method could be further tested in view of the widespread use of open interventional MR units.

Original languageEnglish
Pages (from-to)509-513
Number of pages5
JournalJournal of Computer Assisted Tomography
Volume22
Issue number4
DOIs
Publication statusPublished - 1998

Fingerprint

Volunteers
Magnetic Resonance Imaging
Circle of Willis
Brain
Frontal Lobe
Temporal Lobe
Microcirculation
Healthy Volunteers
Angiography
deoxyhemoglobin

Keywords

  • Arteries, carotid
  • Brain, blood flow
  • Brain, ischemia
  • Functional magnetic resonance imaging (fMRI)

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Radiological and Ultrasound Technology

Cite this

Righini, A., Orsi, M., Tadeo, C. S., Ceccarelli, G., Locatelli, M., Lucchetti, F., ... Cabrini, G. P. (1998). fMRI changes in the brain associated with the carotid compression test. Journal of Computer Assisted Tomography, 22(4), 509-513. https://doi.org/10.1097/00004728-199807000-00001

fMRI changes in the brain associated with the carotid compression test. / Righini, Andrea; Orsi, Massimo; Tadeo, Carlo Sebastiano; Ceccarelli, Giovanni; Locatelli, Marco; Lucchetti, Francesco; Leonardi, Marco; Cabrini, Gian Piero.

In: Journal of Computer Assisted Tomography, Vol. 22, No. 4, 1998, p. 509-513.

Research output: Contribution to journalArticle

Righini, A, Orsi, M, Tadeo, CS, Ceccarelli, G, Locatelli, M, Lucchetti, F, Leonardi, M & Cabrini, GP 1998, 'fMRI changes in the brain associated with the carotid compression test', Journal of Computer Assisted Tomography, vol. 22, no. 4, pp. 509-513. https://doi.org/10.1097/00004728-199807000-00001
Righini, Andrea ; Orsi, Massimo ; Tadeo, Carlo Sebastiano ; Ceccarelli, Giovanni ; Locatelli, Marco ; Lucchetti, Francesco ; Leonardi, Marco ; Cabrini, Gian Piero. / fMRI changes in the brain associated with the carotid compression test. In: Journal of Computer Assisted Tomography. 1998 ; Vol. 22, No. 4. pp. 509-513.
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AU - Righini, Andrea

AU - Orsi, Massimo

AU - Tadeo, Carlo Sebastiano

AU - Ceccarelli, Giovanni

AU - Locatelli, Marco

AU - Lucchetti, Francesco

AU - Leonardi, Marco

AU - Cabrini, Gian Piero

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