fMRI in neurodegenerative diseases: From scientific insights to clinical applications

Bradford C. Dickerson, Federica Agosta, Massimo Filippi

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

fMRI is a technology with great promise as a tool to probe abnormalities of brain activity in neurodegenerative diseases. The detection of functional brain abnormalities may be useful, in the appropriate clinical context, for early diagnosis, differential diagnosis, or prognostication. Prediction of response to treatment or therapeutic monitoring may also be possible with fMRI. In addition, fMRI has the potential to provide a variety of scientific insights that may have clinical relevance, including compensatory hyperactivation of brain circuits or genetic modulation of functional brain activity.

Original languageEnglish
Title of host publicationNeuromethods
PublisherHumana Press Inc.
Pages699-739
Number of pages41
Volume119
DOIs
Publication statusPublished - Sep 1 2016

Publication series

NameNeuromethods
Volume119
ISSN (Print)08932336
ISSN (Electronic)19406045

Keywords

  • Alzheimer’s disease
  • Amyotrophic lateral sclerosis
  • Functional MRI
  • Huntington disease
  • Magnetic resonance imaging
  • Neurodegenerative diseases
  • Parkinson’s disease

ASJC Scopus subject areas

  • Neuroscience(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)
  • Psychiatry and Mental health

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  • Cite this

    Dickerson, B. C., Agosta, F., & Filippi, M. (2016). fMRI in neurodegenerative diseases: From scientific insights to clinical applications. In Neuromethods (Vol. 119, pp. 699-739). (Neuromethods; Vol. 119). Humana Press Inc.. https://doi.org/10.1007/978-1-4939-5611-1_23