fMRI-vs-MEG evaluation of post-stroke interhemispheric asymmetries in primary sensorimotor hand areas

Claudia Altamura, Kahtya Torquati, Filippo Zappasodi, Antonio Ferretti, Vittorio Pizzella, Francesco Tibuzzi, Fabrizio Vernieri, Patrizio Pasqualetti, Doriana Landi, Cosimo Del Gratta, Gian Luca Romani, Paolo Maria Rossini, Franca Tecchio

Research output: Contribution to journalArticlepeer-review

Abstract

Growing evidence emphasizes a positive role of brain ipsilesional (IL) reorganization in stroke patients with partial recovery. Ten patients affected by a monohemispheric stroke in the middle cerebral artery territory underwent functional magnetic resonance (fMRI) and magnetoencephalography (MEG) evaluation of the primary sensory (S1) activation via the same paradigm (median nerve galvanic stimulation). Four patients did not present S1 fMRI activation [Rossini, P.M., Altamura, C., Ferretti, A., Vernieri, F., Zappasodi, F., Caulo, M., Pizzella, V., Del Gratta, C., Romani, G.L., Tecchio, F., 2004. Does cerebrovascular disease affect the coupling between neuronal activity and local haemodynamics? Brain 127, 99-110], although inclusion criteria required bilateral identifiable MEG responses. Mean Euclidean distance between fMRI and MEG S1 activation Talairach coordinates was 10.1 ± 2.9 mm, with a 3D intra-class correlation (ICC) coefficient of 0.986. Interhemispheric asymmetries, evaluated by an MEG procedure independent of Talairach transformation, were outside or at the boundaries of reference ranges in 6 patients. In 3 of them, the IL activation presented medial or lateral shift with respect to the omega-shaped post-rolandic area while in the other 3, IL areas were outside the peri-rolandic region. In conclusion, despite dissociated intensity, the MEG and fMRI activations displayed good spatial consistency in stroke patients, thus confirming excessive interhemispheric asymmetries as a suitable indicator of unusual recruitments in the ipsilesional hemisphere, within or outside the peri-rolandic region.

Original languageEnglish
Pages (from-to)631-639
Number of pages9
JournalExperimental Neurology
Volume204
Issue number2
DOIs
Publication statusPublished - Apr 2007

Keywords

  • Brain mapping
  • Brain reorganization, recovery
  • fMRI
  • MEG
  • Stroke

ASJC Scopus subject areas

  • Neurology
  • Neuroscience(all)

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