FNA and CNB in the diagnosis of pulmonary lesions: A single-center experience on 665 patients, comparison between two periods

Alfonso Vittorio Marchianò, Maria Cosentino, Giuseppe Di Tolla, Francesca Gabriella Greco, Mario Silva, Nicola Sverzellati, Alessandra Fabbri, Elena Tamborini, Giuseppe Lo Russo, Luigi Mariani, Luca Lalli, Ugo Pastorino

Research output: Contribution to journalArticle


Purpose: To evaluate the diagnostic yield and complication rate of 2 different biopsy techniques (fine-needle aspiration, FNA, and core-needle biopsy, CNB) in the diagnosis of pulmonary lesions in 2 distinct periods, 2010-2012 and 2013-2015. Methods: We retrospectively analyzed the results of 691 CT-guided lung biopsies in 665 patients who were divided into 2 groups: cohort 1 (January 2010 to December 2012) was composed of 271 consecutive patients with 284 procedures either by FNA or CNB; cohort 2 (January 2013 to December 2015) was composed of 394 patients with 407 CNBs. Univariate and multivariate logistic regression modeling was used for selected outcomes including diagnostic yield, bleeding and pneumothorax. Results: Cohort 1 comprised 165 men and 106 women (mean age 68.5 years) with 180 FNAs and 104 CNBs; cohort 2 comprised 229 men and 165 women (mean age 66.4 years) with 407 CNBs. The diagnostic yield increased in cohort 2 with respect to cohort 1. There was a slight increase in CT procedure complications (pneumothorax and bleeding) from cohort 1 to cohort 2. The overall risk of complications was greater for lesions ≤20 mm and for lesions at >20 mm distance from the pleura. Conclusions: CT-guided CNB had a higher diagnostic yield than discretional use of either FNA or CNB; there was a slight but acceptable increase in complication rates.

Original languageEnglish
Pages (from-to)360-366
Number of pages7
Issue number4
Publication statusPublished - Jul 1 2017



  • Bleeding
  • Core-needle biopsy (CNB)
  • CT-guided lung biopsy
  • Fine-needle aspiration (FNA)
  • Pneumothorax

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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