Focal adhesion kinase in neuritogenesis

Dario Bonanomi, Flavia Valtorta

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

The transduction of extracellular signals through adhesion and guidance receptors into cytoskeleton reorganization underlies axon outgrowth and pathfinding decisions. The cytoplasmic protein tyrosine kinase focal adhesion kinase (FAK), a central regulator of cell motility phenomena during morphogenesis, is highly expressed in the developing nervous system and selectively enriched in axonal growth cones. Novel studies implicate FAK in the control of neuronal migration and axon behavior during nervous system development. By scaffolding receptorproximal multiprotein complexes, FAK guarantees the integration of adhesive signals derived from the extracellular matrix with guidance cues and growth factors at the level of the developing axons.

Original languageEnglish
Title of host publicationIntracellular Mechanisms for Neuritogenesis
PublisherSpringer US
Pages155-179
Number of pages25
ISBN (Print)038733128X, 9780387331287
DOIs
Publication statusPublished - 2007

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

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  • Cite this

    Bonanomi, D., & Valtorta, F. (2007). Focal adhesion kinase in neuritogenesis. In Intracellular Mechanisms for Neuritogenesis (pp. 155-179). Springer US. https://doi.org/10.1007/978-0-387-68561-8_7