ANOMALIE FOCALI DELLO SVILUPPO CORTICALE ED EPILESSIA: ASPETTI ELETTROCLINICI NELLE MALFORMAZIONI OPERCOLARI BILATERALI

Translated title of the contribution: Focal anomalies of the cortical development and epilepsy: Electroclinical features in the bilateral opercular malformations

R. Guerrini, C. Dravet, A. Battaglia, M. Bureau, J. Roger, C. Raybaud, L. De Pasquale, P. Santanelli, F. Fasano, M. O. Livet, G. Colicchio

Research output: Contribution to journalArticlepeer-review

Abstract

The advanced imaging techniques, particularly MRI, have very much contributed over the last few years to the detection, during life, of structural brain lesions underlying human epilepsy. We studied 9 patients who showed bilateral opercular and/or insular gyration anomalies on MRI. 8 of 9 patients had pseudobulbar palsy (5 'cortical' and 3 'central'), with oromotor incoordination, developmental delay, and varying degrees of mental retardation. Epilepsy was present in all but one case; had a variable age of onset, and a linear evolution in each case: either drug-resistant or well controlled right from the beginning. 4 patients showed drug-resistant seizures with falls; with focal and diffuse EEG abnormalities. Anterior corpus callosotomy in one patient helped the intractable seizures. The other 4 epilepsy cases are well controlled on AEDs.

Translated title of the contributionFocal anomalies of the cortical development and epilepsy: Electroclinical features in the bilateral opercular malformations
Original languageItalian
Pages (from-to)109-111
Number of pages3
JournalBollettino - Lega Italiana contro l'Epilessia
Issue number70-71
Publication statusPublished - 1990

ASJC Scopus subject areas

  • Clinical Neurology

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