The advanced imaging techniques, particularly MRI, have very much contributed over the last few years to the detection, during life, of structural brain lesions underlying human epilepsy. We studied 9 patients who showed bilateral opercular and/or insular gyration anomalies on MRI. 8 of 9 patients had pseudobulbar palsy (5 'cortical' and 3 'central'), with oromotor incoordination, developmental delay, and varying degrees of mental retardation. Epilepsy was present in all but one case; had a variable age of onset, and a linear evolution in each case: either drug-resistant or well controlled right from the beginning. 4 patients showed drug-resistant seizures with falls; with focal and diffuse EEG abnormalities. Anterior corpus callosotomy in one patient helped the intractable seizures. The other 4 epilepsy cases are well controlled on AEDs.
|Translated title of the contribution||Focal anomalies of the cortical development and epilepsy: Electroclinical features in the bilateral opercular malformations|
|Number of pages||3|
|Journal||Bollettino - Lega Italiana contro l'Epilessia|
|Publication status||Published - 1990|
ASJC Scopus subject areas
- Clinical Neurology