Focal areas of increased opacity in ductal carcinoma in situ of the comedo type: Mammographic-pathologic correlation

Karen Kinkel, René Gilles, Chantal Féger, Jean Marc Guinebretière, Anne A. Tardivon, Jacques Masselot, Daniel Vanel

Research output: Contribution to journalArticle

Abstract

PURPOSE: To determine a histopathologic explanation for focal areas of increased opacity on mammograms of ductal carcinoma in situ of the comedo type (comedocarcinoma). MATERIALS AND METHODS: From January 1991 to January 1993, mammograms from 36 patients with comedocarcinomas were reviewed. Each mammogram was screened for microcalcifications and/or any focal area of increased opacity. The presence or absence of infiltrating components was confirmed at pathologic examination, with particular emphasis placed on the search for any stromal reaction. RESULTS: The clinical examination revealed a palpable tumor in five patients (14%) and a bloody discharge from the nipple in two (5%). Isolated clusters of microcalcifications were seen at mammography in 24 patients (67%). Nine patients (25%) had clusters associated with focal areas of increased opacity; three patients (8%) had no microcalcifications. Histologic analysis demonstrated an intense, periductal, inflammatory reaction in all 12 patients with focal areas of increased opacity. CONCLUSION: Focal areas of increased opacity are not always indicative of an infiltrating component and may merely represent intense stromal reaction.

Original languageEnglish
Pages (from-to)443-446
Number of pages4
JournalRadiology
Volume192
Issue number2
Publication statusPublished - Aug 1994

Keywords

  • Breast neoplasms
  • Breast neoplasms, diagnosis

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

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    Kinkel, K., Gilles, R., Féger, C., Guinebretière, J. M., Tardivon, A. A., Masselot, J., & Vanel, D. (1994). Focal areas of increased opacity in ductal carcinoma in situ of the comedo type: Mammographic-pathologic correlation. Radiology, 192(2), 443-446.