Focal cortical dysplasia type IIa and IIb: MRI aspects in 118 cases proven by histopathology

Nadia Colombo; Laura Tassi; Francesco Deleo; Alberto Citterio; Manuela Bramerio; Roberto Mai; Ivana Sartori; Francesco Cardinale; Giorgio Lo Russo; Roberto Spreafico

doi:10.1007/s00234-012-1049-1

Focal cortical dysplasia type IIa and IIb: MRI aspects in 118 cases proven by histopathology

Nadia Colombo, Laura Tassi, Francesco Deleo, Alberto Citterio, Manuela Bramerio, Roberto Mai, Ivana Sartori, Francesco Cardinale, Giorgio Lo Russo, Roberto Spreafico

Fondazione IRCCS Istituto Neurologico "C. Besta"

Research output: Contribution to journal › Article › peer-review

Abstract

Introduction: This study aims to review the magnetic resonance imaging (MRI) aspects of a large series of patients with focal cortical dysplasia type II (FCD II) and attempt to identify distinctive features in the two histopathological subtypes IIa and IIb. Methods: We retrospectively reviewed the MRI scans of 118 patients with histological proven FCD IIa (n∈=∈37) or IIb (n∈=∈81) who were surgically treated for intractable epilepsy. Results: MRI was abnormal in 93 patients (79 %) and unremarkable in 25 (21 %). A dysplastic lesion was identified in 90 cases (97 %) and classified as FCD II in 83 and FCD non-II in seven cases. In three cases, the MRI diagnosis was other than FCD. There was a significant association between the presence of cortical thickening (p∈=∈0.002) and the transmantle sign (p∈

Original language	English
Pages (from-to)	1065-1077
Number of pages	13
Journal	Neuroradiology
Volume	54
Issue number	10
DOIs	https://doi.org/10.1007/s00234-012-1049-1
Publication status	Published - Oct 2012

Keywords

Epilepsy
Focal cortical dysplasia type IIa and IIb
MRI imaging

ASJC Scopus subject areas

Radiology Nuclear Medicine and imaging
Clinical Neurology
Cardiology and Cardiovascular Medicine

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Focal cortical dysplasia type IIa and IIb : MRI aspects in 118 cases proven by histopathology. / Colombo, Nadia; Tassi, Laura; Deleo, Francesco; Citterio, Alberto; Bramerio, Manuela; Mai, Roberto; Sartori, Ivana; Cardinale, Francesco; Lo Russo, Giorgio; Spreafico, Roberto.

In: Neuroradiology, Vol. 54, No. 10, 10.2012, p. 1065-1077.

Research output: Contribution to journal › Article › peer-review

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abstract = "Introduction: This study aims to review the magnetic resonance imaging (MRI) aspects of a large series of patients with focal cortical dysplasia type II (FCD II) and attempt to identify distinctive features in the two histopathological subtypes IIa and IIb. Methods: We retrospectively reviewed the MRI scans of 118 patients with histological proven FCD IIa (n∈=∈37) or IIb (n∈=∈81) who were surgically treated for intractable epilepsy. Results: MRI was abnormal in 93 patients (79 %) and unremarkable in 25 (21 %). A dysplastic lesion was identified in 90 cases (97 %) and classified as FCD II in 83 and FCD non-II in seven cases. In three cases, the MRI diagnosis was other than FCD. There was a significant association between the presence of cortical thickening (p∈=∈0.002) and the transmantle sign (p∈",

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AU - Bramerio, Manuela

AU - Mai, Roberto

AU - Sartori, Ivana

AU - Cardinale, Francesco

AU - Lo Russo, Giorgio

AU - Spreafico, Roberto

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