Focal cortical dysplasia type IIa and IIb: MRI aspects in 118 cases proven by histopathology

Nadia Colombo, Laura Tassi, Francesco Deleo, Alberto Citterio, Manuela Bramerio, Roberto Mai, Ivana Sartori, Francesco Cardinale, Giorgio Lo Russo, Roberto Spreafico

Research output: Contribution to journalArticlepeer-review


Introduction: This study aims to review the magnetic resonance imaging (MRI) aspects of a large series of patients with focal cortical dysplasia type II (FCD II) and attempt to identify distinctive features in the two histopathological subtypes IIa and IIb. Methods: We retrospectively reviewed the MRI scans of 118 patients with histological proven FCD IIa (n∈=∈37) or IIb (n∈=∈81) who were surgically treated for intractable epilepsy. Results: MRI was abnormal in 93 patients (79 %) and unremarkable in 25 (21 %). A dysplastic lesion was identified in 90 cases (97 %) and classified as FCD II in 83 and FCD non-II in seven cases. In three cases, the MRI diagnosis was other than FCD. There was a significant association between the presence of cortical thickening (p∈=∈0.002) and the transmantle sign (p∈

Original languageEnglish
Pages (from-to)1065-1077
Number of pages13
Issue number10
Publication statusPublished - Oct 2012


  • Epilepsy
  • Focal cortical dysplasia type IIa and IIb
  • MRI imaging

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Cardiology and Cardiovascular Medicine


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