Focal electroretinograms and fundus appearance in nonexudative age-related macular degeneration. Quantitative relationship between retinal morphology and function

Benedetto Falsini, Sebastiano Serrao, Antonello Fadda, Giancarlo Iarossi, Giovanni Porrello, Francesco Cocco, Erasmo Merendino

Research output: Contribution to journalArticle

31 Citations (Scopus)

Abstract

Background: The aim of this study was to evaluate the focal electroretinogram (FERG), an objective indicator of outer retinal function, in nonexudative age-related macular degeneration (NE-AMD), and to compare FERG results with morphological lesions assessed by stereoscopic fundus photographs and fluorescein angiograms. Methods: Twenty-five patients (25 eyes) with bilateral NE-AMD (visual acuity of the study eyes ≥ 0.4) as well as 10 age- and sex-matched control subjects (10 eyes) were evaluated. FERGs were recorded from the macular region (9°) in response to sinusoidal stimuli flickered at 32 Hz. Amplitude and phase angle of the Fourier-analyzed FERG fundamental component were measured. Fundus lesions were graded from color slides according to the Wisconsin age-related maculopathy grading system. Fluorescein angiograms were evaluated by an image analysis technique to compute the area with pathological hyperfluorescence (associated with drusen and/or retinal pigment epithelial atrophy) within the macular (approximately 9°x 9°) region. Results: Compared to control eyes, NE-AMD eyes had a reduction in the mean FERG amplitude (57% loss, P <0.001) with no phase changes. Amplitudes of individual affected eyes were negatively correlated with either the Wisconsin grading score (r = -0.63, P <0.001) or the percentage area of pathological hyperfluorescence (r = -0.70, P <0.01). Eyes with minimal NE-AMD lesions (Wisconsin score ≤ 6) and normal acuity had a lower mean amplitude (47% loss, P <0.05) than that of control eyes. Conclusions: The results indicate that, in NE-AMD, the FERG is altered in parallel with the extent and severity of fundus lesions. However, a functional impairment of outer macular layers, which is detected by FERG losses, could precede morphological changes typical of more advanced disease.

Original languageEnglish
Pages (from-to)193-200
Number of pages8
JournalGraefe's Archive for Clinical and Experimental Ophthalmology
Volume237
Issue number3
DOIs
Publication statusPublished - Mar 1999

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Macular Degeneration
Fluorescein
Angiography
Retinal Pigments
Visual Acuity
Atrophy
Color

ASJC Scopus subject areas

  • Ophthalmology

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Focal electroretinograms and fundus appearance in nonexudative age-related macular degeneration. Quantitative relationship between retinal morphology and function. / Falsini, Benedetto; Serrao, Sebastiano; Fadda, Antonello; Iarossi, Giancarlo; Porrello, Giovanni; Cocco, Francesco; Merendino, Erasmo.

In: Graefe's Archive for Clinical and Experimental Ophthalmology, Vol. 237, No. 3, 03.1999, p. 193-200.

Research output: Contribution to journalArticle

Falsini, Benedetto ; Serrao, Sebastiano ; Fadda, Antonello ; Iarossi, Giancarlo ; Porrello, Giovanni ; Cocco, Francesco ; Merendino, Erasmo. / Focal electroretinograms and fundus appearance in nonexudative age-related macular degeneration. Quantitative relationship between retinal morphology and function. In: Graefe's Archive for Clinical and Experimental Ophthalmology. 1999 ; Vol. 237, No. 3. pp. 193-200.
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abstract = "Background: The aim of this study was to evaluate the focal electroretinogram (FERG), an objective indicator of outer retinal function, in nonexudative age-related macular degeneration (NE-AMD), and to compare FERG results with morphological lesions assessed by stereoscopic fundus photographs and fluorescein angiograms. Methods: Twenty-five patients (25 eyes) with bilateral NE-AMD (visual acuity of the study eyes ≥ 0.4) as well as 10 age- and sex-matched control subjects (10 eyes) were evaluated. FERGs were recorded from the macular region (9°) in response to sinusoidal stimuli flickered at 32 Hz. Amplitude and phase angle of the Fourier-analyzed FERG fundamental component were measured. Fundus lesions were graded from color slides according to the Wisconsin age-related maculopathy grading system. Fluorescein angiograms were evaluated by an image analysis technique to compute the area with pathological hyperfluorescence (associated with drusen and/or retinal pigment epithelial atrophy) within the macular (approximately 9°x 9°) region. Results: Compared to control eyes, NE-AMD eyes had a reduction in the mean FERG amplitude (57{\%} loss, P <0.001) with no phase changes. Amplitudes of individual affected eyes were negatively correlated with either the Wisconsin grading score (r = -0.63, P <0.001) or the percentage area of pathological hyperfluorescence (r = -0.70, P <0.01). Eyes with minimal NE-AMD lesions (Wisconsin score ≤ 6) and normal acuity had a lower mean amplitude (47{\%} loss, P <0.05) than that of control eyes. Conclusions: The results indicate that, in NE-AMD, the FERG is altered in parallel with the extent and severity of fundus lesions. However, a functional impairment of outer macular layers, which is detected by FERG losses, could precede morphological changes typical of more advanced disease.",
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AU - Serrao, Sebastiano

AU - Fadda, Antonello

AU - Iarossi, Giancarlo

AU - Porrello, Giovanni

AU - Cocco, Francesco

AU - Merendino, Erasmo

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