Focal epilepsies associated with Glioneuronal tumors: Review article

M. Giulioni, G. Rubboli, G. Marucci, M. Martinoni, A. F. Marliani, F. Bartiromo, F. Calbucci

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Glioneuronal tumors (GNTs) are an increasingly recognized cause of focal epilepsies, particularly in children and young adults. GNTs consist of a mixture of glial and neuronal elements and most commonly arise in the temporal lobe, particularly in the temporo-anterior-basal mesial site. They are often associated with cortical dysplasia or other neuronal migration abnormalities. Epilepsy associated with GNT is poorly controlled by antiepileptic drugs in many cases; but, it is extremely responsive to surgical treatment. However, the best management strategy of tumor-related focal epilepsies remains controversial and still remain one of the contemporary issues in epilepsy surgery. Temporo-mesial GNT are associated with a widespread epileptic network, defining, therefore, a distinct anatomo-clinico-pathological group with complex epileptogenic mechanisms. By using an epilepsy surgery oriented strategy GNT associated with focal epilepsies may have an excellent seizure outcome and, therefore, surgical treatment can be offered early to avoid both the consequences of uncontrolled seizures as well as the side effects of prolonged pharmacological therapy and the rare risk of tumor growth or malignant transformation.

Original languageEnglish
Pages (from-to)225-238
Number of pages14
JournalPanminerva Medica
Volume55
Issue number2
Publication statusPublished - Jun 2013

Fingerprint

Partial Epilepsy
Neoplasms
Epilepsy
Seizures
Malformations of Cortical Development
Temporal Lobe
Neuroglia
Anticonvulsants
Young Adult
Therapeutics
Pharmacology
Growth

Keywords

  • Child
  • Epilepsy
  • Neoplasms
  • Neoplasms, neuroepithelial

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Giulioni, M., Rubboli, G., Marucci, G., Martinoni, M., Marliani, A. F., Bartiromo, F., & Calbucci, F. (2013). Focal epilepsies associated with Glioneuronal tumors: Review article. Panminerva Medica, 55(2), 225-238.

Focal epilepsies associated with Glioneuronal tumors : Review article. / Giulioni, M.; Rubboli, G.; Marucci, G.; Martinoni, M.; Marliani, A. F.; Bartiromo, F.; Calbucci, F.

In: Panminerva Medica, Vol. 55, No. 2, 06.2013, p. 225-238.

Research output: Contribution to journalArticle

Giulioni, M, Rubboli, G, Marucci, G, Martinoni, M, Marliani, AF, Bartiromo, F & Calbucci, F 2013, 'Focal epilepsies associated with Glioneuronal tumors: Review article', Panminerva Medica, vol. 55, no. 2, pp. 225-238.
Giulioni M, Rubboli G, Marucci G, Martinoni M, Marliani AF, Bartiromo F et al. Focal epilepsies associated with Glioneuronal tumors: Review article. Panminerva Medica. 2013 Jun;55(2):225-238.
Giulioni, M. ; Rubboli, G. ; Marucci, G. ; Martinoni, M. ; Marliani, A. F. ; Bartiromo, F. ; Calbucci, F. / Focal epilepsies associated with Glioneuronal tumors : Review article. In: Panminerva Medica. 2013 ; Vol. 55, No. 2. pp. 225-238.
@article{38fdbeae47634994aa5c9370cb38ad42,
title = "Focal epilepsies associated with Glioneuronal tumors: Review article",
abstract = "Glioneuronal tumors (GNTs) are an increasingly recognized cause of focal epilepsies, particularly in children and young adults. GNTs consist of a mixture of glial and neuronal elements and most commonly arise in the temporal lobe, particularly in the temporo-anterior-basal mesial site. They are often associated with cortical dysplasia or other neuronal migration abnormalities. Epilepsy associated with GNT is poorly controlled by antiepileptic drugs in many cases; but, it is extremely responsive to surgical treatment. However, the best management strategy of tumor-related focal epilepsies remains controversial and still remain one of the contemporary issues in epilepsy surgery. Temporo-mesial GNT are associated with a widespread epileptic network, defining, therefore, a distinct anatomo-clinico-pathological group with complex epileptogenic mechanisms. By using an epilepsy surgery oriented strategy GNT associated with focal epilepsies may have an excellent seizure outcome and, therefore, surgical treatment can be offered early to avoid both the consequences of uncontrolled seizures as well as the side effects of prolonged pharmacological therapy and the rare risk of tumor growth or malignant transformation.",
keywords = "Child, Epilepsy, Neoplasms, Neoplasms, neuroepithelial",
author = "M. Giulioni and G. Rubboli and G. Marucci and M. Martinoni and Marliani, {A. F.} and F. Bartiromo and F. Calbucci",
year = "2013",
month = "6",
language = "English",
volume = "55",
pages = "225--238",
journal = "Panminerva Medica",
issn = "0031-0808",
publisher = "Edizioni Minerva Medica S.p.A.",
number = "2",

}

TY - JOUR

T1 - Focal epilepsies associated with Glioneuronal tumors

T2 - Review article

AU - Giulioni, M.

AU - Rubboli, G.

AU - Marucci, G.

AU - Martinoni, M.

AU - Marliani, A. F.

AU - Bartiromo, F.

AU - Calbucci, F.

PY - 2013/6

Y1 - 2013/6

N2 - Glioneuronal tumors (GNTs) are an increasingly recognized cause of focal epilepsies, particularly in children and young adults. GNTs consist of a mixture of glial and neuronal elements and most commonly arise in the temporal lobe, particularly in the temporo-anterior-basal mesial site. They are often associated with cortical dysplasia or other neuronal migration abnormalities. Epilepsy associated with GNT is poorly controlled by antiepileptic drugs in many cases; but, it is extremely responsive to surgical treatment. However, the best management strategy of tumor-related focal epilepsies remains controversial and still remain one of the contemporary issues in epilepsy surgery. Temporo-mesial GNT are associated with a widespread epileptic network, defining, therefore, a distinct anatomo-clinico-pathological group with complex epileptogenic mechanisms. By using an epilepsy surgery oriented strategy GNT associated with focal epilepsies may have an excellent seizure outcome and, therefore, surgical treatment can be offered early to avoid both the consequences of uncontrolled seizures as well as the side effects of prolonged pharmacological therapy and the rare risk of tumor growth or malignant transformation.

AB - Glioneuronal tumors (GNTs) are an increasingly recognized cause of focal epilepsies, particularly in children and young adults. GNTs consist of a mixture of glial and neuronal elements and most commonly arise in the temporal lobe, particularly in the temporo-anterior-basal mesial site. They are often associated with cortical dysplasia or other neuronal migration abnormalities. Epilepsy associated with GNT is poorly controlled by antiepileptic drugs in many cases; but, it is extremely responsive to surgical treatment. However, the best management strategy of tumor-related focal epilepsies remains controversial and still remain one of the contemporary issues in epilepsy surgery. Temporo-mesial GNT are associated with a widespread epileptic network, defining, therefore, a distinct anatomo-clinico-pathological group with complex epileptogenic mechanisms. By using an epilepsy surgery oriented strategy GNT associated with focal epilepsies may have an excellent seizure outcome and, therefore, surgical treatment can be offered early to avoid both the consequences of uncontrolled seizures as well as the side effects of prolonged pharmacological therapy and the rare risk of tumor growth or malignant transformation.

KW - Child

KW - Epilepsy

KW - Neoplasms

KW - Neoplasms, neuroepithelial

UR - http://www.scopus.com/inward/record.url?scp=84880120372&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880120372&partnerID=8YFLogxK

M3 - Article

C2 - 23676963

AN - SCOPUS:84880120372

VL - 55

SP - 225

EP - 238

JO - Panminerva Medica

JF - Panminerva Medica

SN - 0031-0808

IS - 2

ER -