Focal epileptic seizure induced by transient hypoglycaemia in insulin-treated diabetes

Leonardo Lapenta, Carlo Di Bonaventura, Jinane Fattouch, Francesca Bonini, Simona Petrucci, Silvia Gagliardi, Sara Casciato, Mario Manfredi, Massimiliano Prencipe, Anna Teresa Giallonardo

Research output: Contribution to journalArticlepeer-review


Hypoglycaemia, common in diabetic patients treated with insulin, can induce various neurological disturbances. Of these, seizures are the most common acute symptom, mainly of the generalised tonic-clonic type, with focal events only exceptionally being reported and documented. Hypoglycaemia can modify cortical excitability by determining an imbalance between excitation and inhibition; some brain structures, such as the temporal lobe and hippocampus, appear to be particularly susceptible to this insult. We describe a case of a 61-year-old diabetic patient in whom insulin-induced transient hypoglycaemia triggered a focal seizure of temporal origin that was well documented by EEG during 24-hour ambulatory monitoring. This is, to our knowledge, one of the few, well-documented cases of this type of seizure.

Original languageEnglish
Pages (from-to)84-87
Number of pages4
JournalEpileptic Disorders
Issue number1
Publication statusPublished - Mar 2010


  • Acute symptom
  • Diabetes
  • Epileptic seizure
  • Hypoglycaemia

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology


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