Focal nodular hyperplasia and hepatic regenerating nodules in pediatric oncology patients: How much invasive approach is necessary?

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Abstract

Introduction. Hepatic regenerating nodules (HRN) and focal nodular hyperplasia (FNH) are benign regenerating lesions of the liver that rarely occur in children. An increased incidence of these lesions is reported in children treated for cancer. Material and methods. Eight children who developed FNH and HRN after treatment for malignancies in the Oncology unit at the "Bambino Gesù" Pediatric Hospital in Rome, were retrospectively analyzed. Results. The lesions, considered in the differential diagnosis with metastatic relapse of the primitive disease, have been monitored with US or other available imaging techniques. Evolution of the lesions was observed in only 1 patient three years after the initial diagnosis of FNH. Conclusion. In conclusion serial monitoring with imaging techniques is sufficient to rule out liver metastasis and to monitor the evolution of the lesions. Surgery is suggested only in the case of complications.

Original languageEnglish
Pages (from-to)308-314
Number of pages7
JournalAnnals of Hepatology
Volume12
Issue number2
Publication statusPublished - Mar 2013

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Focal Nodular Hyperplasia
Pediatrics
Liver
Pediatric Hospitals
Neoplasms
Differential Diagnosis
Neoplasm Metastasis
Recurrence
Incidence

Keywords

  • Chemotherapy
  • Childhood
  • Hepatic focal nodular hyperplasia

ASJC Scopus subject areas

  • Hepatology

Cite this

@article{02c0b380855248a29259389020ba4537,
title = "Focal nodular hyperplasia and hepatic regenerating nodules in pediatric oncology patients: How much invasive approach is necessary?",
abstract = "Introduction. Hepatic regenerating nodules (HRN) and focal nodular hyperplasia (FNH) are benign regenerating lesions of the liver that rarely occur in children. An increased incidence of these lesions is reported in children treated for cancer. Material and methods. Eight children who developed FNH and HRN after treatment for malignancies in the Oncology unit at the {"}Bambino Ges{\`u}{"} Pediatric Hospital in Rome, were retrospectively analyzed. Results. The lesions, considered in the differential diagnosis with metastatic relapse of the primitive disease, have been monitored with US or other available imaging techniques. Evolution of the lesions was observed in only 1 patient three years after the initial diagnosis of FNH. Conclusion. In conclusion serial monitoring with imaging techniques is sufficient to rule out liver metastasis and to monitor the evolution of the lesions. Surgery is suggested only in the case of complications.",
keywords = "Chemotherapy, Childhood, Hepatic focal nodular hyperplasia",
author = "{De Pasquale}, {Maria Debora} and Lidia Monti and {Luisa D'Andrea}, Maria and {De Ioris}, {Maria Antonietta} and Aurora Castellano",
year = "2013",
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language = "English",
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pages = "308--314",
journal = "Annals of Hepatology",
issn = "1665-2681",
publisher = "Mexican Association of Hepatology",
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TY - JOUR

T1 - Focal nodular hyperplasia and hepatic regenerating nodules in pediatric oncology patients

T2 - How much invasive approach is necessary?

AU - De Pasquale, Maria Debora

AU - Monti, Lidia

AU - Luisa D'Andrea, Maria

AU - De Ioris, Maria Antonietta

AU - Castellano, Aurora

PY - 2013/3

Y1 - 2013/3

N2 - Introduction. Hepatic regenerating nodules (HRN) and focal nodular hyperplasia (FNH) are benign regenerating lesions of the liver that rarely occur in children. An increased incidence of these lesions is reported in children treated for cancer. Material and methods. Eight children who developed FNH and HRN after treatment for malignancies in the Oncology unit at the "Bambino Gesù" Pediatric Hospital in Rome, were retrospectively analyzed. Results. The lesions, considered in the differential diagnosis with metastatic relapse of the primitive disease, have been monitored with US or other available imaging techniques. Evolution of the lesions was observed in only 1 patient three years after the initial diagnosis of FNH. Conclusion. In conclusion serial monitoring with imaging techniques is sufficient to rule out liver metastasis and to monitor the evolution of the lesions. Surgery is suggested only in the case of complications.

AB - Introduction. Hepatic regenerating nodules (HRN) and focal nodular hyperplasia (FNH) are benign regenerating lesions of the liver that rarely occur in children. An increased incidence of these lesions is reported in children treated for cancer. Material and methods. Eight children who developed FNH and HRN after treatment for malignancies in the Oncology unit at the "Bambino Gesù" Pediatric Hospital in Rome, were retrospectively analyzed. Results. The lesions, considered in the differential diagnosis with metastatic relapse of the primitive disease, have been monitored with US or other available imaging techniques. Evolution of the lesions was observed in only 1 patient three years after the initial diagnosis of FNH. Conclusion. In conclusion serial monitoring with imaging techniques is sufficient to rule out liver metastasis and to monitor the evolution of the lesions. Surgery is suggested only in the case of complications.

KW - Chemotherapy

KW - Childhood

KW - Hepatic focal nodular hyperplasia

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