Focus on GH deficiency and thyroid function

Claudia Giavoli; Eriselda Profka; Giulia Rodari; Andrea Lania; Paolo Beck-Peccoz

doi:10.1016/j.beem.2017.02.003

Focus on GH deficiency and thyroid function

Claudia Giavoli, Eriselda Profka, Giulia Rodari, Andrea Lania, Paolo Beck-Peccoz

Research output: Contribution to journal › Review article › peer-review

Abstract

The relationships between GH system and hypothalamic–pituitary–thyroid axis are complex and not yet fully understood. The reported effects of GH administration on thyroid status of GHD patients have been remarkably divergent. This review will focus on the main studies aimed to clarify the effects of GH on thyroid function, firstly going through the diagnosis of central hypothyroidism and its possible pitfalls, then elucidating the possible contexts in which GHD may develop and examining the proposed mechanisms at the basis of interactions between the GH-IGF-I system and the hypothalamic–pituitary–thyroid axis.

Original language	English
Pages (from-to)	71-78
Number of pages	8
Journal	Best Practice and Research: Clinical Endocrinology and Metabolism
Volume	31
Issue number	1
DOIs	https://doi.org/10.1016/j.beem.2017.02.003
Publication status	Published - Feb 1 2017

Keywords

central hypothyroidism
growth hormone deficient adults
L-T4 replacement therapy
recombinant hGH
thyroid function

ASJC Scopus subject areas

Endocrinology, Diabetes and Metabolism
Endocrinology

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AU - Giavoli, Claudia

AU - Profka, Eriselda

AU - Rodari, Giulia

AU - Lania, Andrea

AU - Beck-Peccoz, Paolo

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AB - The relationships between GH system and hypothalamic–pituitary–thyroid axis are complex and not yet fully understood. The reported effects of GH administration on thyroid status of GHD patients have been remarkably divergent. This review will focus on the main studies aimed to clarify the effects of GH on thyroid function, firstly going through the diagnosis of central hypothyroidism and its possible pitfalls, then elucidating the possible contexts in which GHD may develop and examining the proposed mechanisms at the basis of interactions between the GH-IGF-I system and the hypothalamic–pituitary–thyroid axis.

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KW - L-T4 replacement therapy

KW - recombinant hGH

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Focus on GH deficiency and thyroid function

Abstract

Keywords

ASJC Scopus subject areas

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