Focus on GH deficiency and thyroid function

Claudia Giavoli, Eriselda Profka, Giulia Rodari, Andrea Lania, Paolo Beck-Peccoz

Research output: Contribution to journalReview articlepeer-review


The relationships between GH system and hypothalamic–pituitary–thyroid axis are complex and not yet fully understood. The reported effects of GH administration on thyroid status of GHD patients have been remarkably divergent. This review will focus on the main studies aimed to clarify the effects of GH on thyroid function, firstly going through the diagnosis of central hypothyroidism and its possible pitfalls, then elucidating the possible contexts in which GHD may develop and examining the proposed mechanisms at the basis of interactions between the GH-IGF-I system and the hypothalamic–pituitary–thyroid axis.

Original languageEnglish
Pages (from-to)71-78
Number of pages8
JournalBest Practice and Research: Clinical Endocrinology and Metabolism
Issue number1
Publication statusPublished - Feb 1 2017


  • central hypothyroidism
  • growth hormone deficient adults
  • L-T4 replacement therapy
  • recombinant hGH
  • thyroid function

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Endocrinology


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