Focus on GH deficiency and thyroid function

Claudia Giavoli; Eriselda Profka; Giulia Rodari; Andrea Lania; Paolo Beck-Peccoz

doi:10.1016/j.beem.2017.02.003

Focus on GH deficiency and thyroid function

Claudia Giavoli, Eriselda Profka, Giulia Rodari, Andrea Lania, Paolo Beck-Peccoz

Research output: Contribution to journal › Review article › peer-review

Abstract

The relationships between GH system and hypothalamic-pituitary-thyroid axis are complex and not yet fully understood. The reported effects of GH administration on thyroid status of GHD patients have been remarkably divergent. This review will focus on the main studies aimed to clarify the effects of GH on thyroid function, firstly going through the diagnosis of central hypothyroidism and its possible pitfalls, then elucidating the possible contexts in which GHD may develop and examining the proposed mechanisms at the basis of interactions between the GH-IGF-I system and the hypothalamic-pituitary-thyroid axis.

Original language	English
Pages (from-to)	71-78
Number of pages	8
Journal	Best Practice and Research in Clinical Endocrinology and Metabolism
Volume	31
Issue number	1
DOIs	https://doi.org/10.1016/j.beem.2017.02.003
Publication status	Published - Feb 2017

Keywords

Female
Hormone Replacement Therapy
Human Growth Hormone
Humans
Hypothalamo-Hypophyseal System
Hypothyroidism
Insulin-Like Growth Factor I
Male
Pituitary Hormones
Thyroid Gland
Journal Article
Review

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title = "Focus on GH deficiency and thyroid function",

abstract = "The relationships between GH system and hypothalamic-pituitary-thyroid axis are complex and not yet fully understood. The reported effects of GH administration on thyroid status of GHD patients have been remarkably divergent. This review will focus on the main studies aimed to clarify the effects of GH on thyroid function, firstly going through the diagnosis of central hypothyroidism and its possible pitfalls, then elucidating the possible contexts in which GHD may develop and examining the proposed mechanisms at the basis of interactions between the GH-IGF-I system and the hypothalamic-pituitary-thyroid axis.",

keywords = "Female, Hormone Replacement Therapy, Human Growth Hormone, Humans, Hypothalamo-Hypophyseal System, Hypothyroidism, Insulin-Like Growth Factor I, Male, Pituitary Hormones, Thyroid Gland, Journal Article, Review",

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AU - Giavoli, Claudia

AU - Profka, Eriselda

AU - Rodari, Giulia

AU - Lania, Andrea

AU - Beck-Peccoz, Paolo

PY - 2017/2

Y1 - 2017/2

N2 - The relationships between GH system and hypothalamic-pituitary-thyroid axis are complex and not yet fully understood. The reported effects of GH administration on thyroid status of GHD patients have been remarkably divergent. This review will focus on the main studies aimed to clarify the effects of GH on thyroid function, firstly going through the diagnosis of central hypothyroidism and its possible pitfalls, then elucidating the possible contexts in which GHD may develop and examining the proposed mechanisms at the basis of interactions between the GH-IGF-I system and the hypothalamic-pituitary-thyroid axis.

AB - The relationships between GH system and hypothalamic-pituitary-thyroid axis are complex and not yet fully understood. The reported effects of GH administration on thyroid status of GHD patients have been remarkably divergent. This review will focus on the main studies aimed to clarify the effects of GH on thyroid function, firstly going through the diagnosis of central hypothyroidism and its possible pitfalls, then elucidating the possible contexts in which GHD may develop and examining the proposed mechanisms at the basis of interactions between the GH-IGF-I system and the hypothalamic-pituitary-thyroid axis.

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KW - Hormone Replacement Therapy

KW - Human Growth Hormone

KW - Humans

KW - Hypothalamo-Hypophyseal System

KW - Hypothyroidism

KW - Insulin-Like Growth Factor I

KW - Male

KW - Pituitary Hormones

KW - Thyroid Gland

KW - Journal Article

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JO - Best Practice and Research in Clinical Endocrinology and Metabolism

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