Focus on the actual clinical target volume irradiated with intraoperative radiotherapy for breast cancer

Marina Guenzi, Alessandra Fozza, Gladys Blandino, Giorgia Timon, Liliana Belgioia, Giulia Vidano, Francesca Cavagnetto, Marco Gusinu, Stefano Agostinelli, Stefania Garelli, Michele Zeverino, Gianni Taccini, Renzo Corvò

Research output: Contribution to journalArticlepeer-review


Aim: Intraoperative radiotherapy (IORT) has been investigated as an exclusive adjuvant treatment option for early-stage breast cancer (BC). We analysed our experience on the technical aspects of this innovative approach in terms of identification of breast volume actually to be treated during IORT. Patients and Methods: A total of 315 patients at low risk of breast cancer recurrence underwent IORT as exclusive treatment after breastconservative surgery. To evaluate the breast volume actually irradiated with IORT, we considered a sample of eight patients, chosen retrospectively as having enough clips to identify the tumour bed and IORT site in computedtomography (CT). The clinical target volume (CTV) was assessed for each patient with two different methods: the first, cc-IORT, was considered during surgery according to the chosen collimator diameter and glandular thickness, while the second, cc-CT, was evaluated through computedtomography performed after surgery. The cc-CT CTV was obtained by contouring the cc-IORT on the CT section on the basis of the clips placed by the surgeon on the resection margins. Results: In our experience, the 5-cm (50%) and the 6-cm (36%) diameter collimators have been the ones, used the most. The diameter of the collimator used did not appear to adversely affect the satisfactory aesthetic result. The comparison between CTVs showed that glandular breast volume contoured with CT (cc-CT) appeared to be three fold larger than the target identified at surgery and included in the area of chosen collimator (cc-IORT). Conclusion: The actual volume of breast gland irradiated with the IORT procedure appears to be larger than expected. This may be due to the area being prepared for IORT by placing tissue compactly.

Original languageEnglish
Pages (from-to)4945-4950
Number of pages6
JournalAnticancer Research
Issue number11
Publication statusPublished - Nov 2012


  • Breast cancer
  • Clinical target volume
  • Intraoperative radiotherapy

ASJC Scopus subject areas

  • Cancer Research
  • Oncology


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