Foetal pulmonary maturation in pregnancies complicated by diabetes and Rh immunization

G. Pardi, M. Buscaglia, A. Kustermann, P. Bozzetti, M. M. Ferrari, A. M. Marconi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

In pregnancies complicated by diabetes, foetal lung maturation depends on a good control of maternal blood glucose values. In poorly controlled maternal diabetes, foetal hyperinsulinaemia may cause a delay in pulmonary maturation. There was no single case of respiratory distress syndrome (RDS) in 112 pregnant class B-F diabetic patients that we treated with high doses of insulin. Furthermore, in a controlled randomized trial of diet versus insulin treatment in class A diabetes we found no differences in perinatal mortality in patients with adequate metabolic control. In pregnancies complicated by Rh isoimmunization, determination of phosphatidylglycerol in amniotic fluid is a more reliable marker of foetal lung maturity than is the lecithin/sphingomyelin ratio. The marked decrease in perinatal mortality due to Rh incompatibility observed in recent years depends on several factors including administration of corticosteroids to the mother to prevent RDS, irrespective of whether amniotic fluid parameters indicate foetal lung maturity.

Original languageEnglish
JournalEuropean Respiratory Journal
Volume1
Issue numberSUPPL. 3
Publication statusPublished - 1989

Fingerprint

Pregnancy in Diabetics
Immunization
Lung
Perinatal Mortality
Mothers
Amniotic Fluid
Rh Isoimmunization
Insulin
Phosphatidylglycerols
Sphingomyelins
Lecithins
Hyperinsulinism
Blood Glucose
Adrenal Cortex Hormones
Randomized Controlled Trials
Diet
Pregnancy

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Pardi, G., Buscaglia, M., Kustermann, A., Bozzetti, P., Ferrari, M. M., & Marconi, A. M. (1989). Foetal pulmonary maturation in pregnancies complicated by diabetes and Rh immunization. European Respiratory Journal, 1(SUPPL. 3).

Foetal pulmonary maturation in pregnancies complicated by diabetes and Rh immunization. / Pardi, G.; Buscaglia, M.; Kustermann, A.; Bozzetti, P.; Ferrari, M. M.; Marconi, A. M.

In: European Respiratory Journal, Vol. 1, No. SUPPL. 3, 1989.

Research output: Contribution to journalArticle

Pardi, G, Buscaglia, M, Kustermann, A, Bozzetti, P, Ferrari, MM & Marconi, AM 1989, 'Foetal pulmonary maturation in pregnancies complicated by diabetes and Rh immunization', European Respiratory Journal, vol. 1, no. SUPPL. 3.
Pardi, G. ; Buscaglia, M. ; Kustermann, A. ; Bozzetti, P. ; Ferrari, M. M. ; Marconi, A. M. / Foetal pulmonary maturation in pregnancies complicated by diabetes and Rh immunization. In: European Respiratory Journal. 1989 ; Vol. 1, No. SUPPL. 3.
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