Folate in gastrointestinal health and disease

F. R. Ponziani, I. A. Cazzato, S. Danese, S. Fagiuoli, P. Gionchetti, B. E. Annicchiarico, F. D'Aversa, A. Gasbarrini

Research output: Contribution to journalArticle

Abstract

Objective: Folate has heterogeneous functions and is involved in several activities in both animal and human body. It is an important constituent of our organism, and its bioavailability is mainly dependent from the correct function of our gastrointestinal tract. Our aim is to describe what happens to folate homeostasis in gastrointestinal health and disease, analyzing the alterations of folate metabolism in some specific conditions of intestinal and liver impairment. Discussion: Folate absorption and metabolization involve the small intestine and the liver; in conditions of gastrointestinal tract disease (i.e. celiac disease, liver disease) folate function may be compromised with important consequences on the whole organism. Moreover, folate deficiency may produce gastrointestinal alterations too. For this reason, the gastrointestinal tract could be the responsible but also the victim of folate deficiency. Conclusions: The presence of folate deficiency should always be assessed in patients with a gastrointestinal disease. Further studies are needed to assess the role of folates in gastrointestinal tract diseases and in other gynecologic, neurologic, psychiatric, cardiovascular, ophthalmic and neoplastic diseases. Folates supplementation could be considered, in the future, as an effective complimentary therapy in several pathologic conditions.

Original languageEnglish
Pages (from-to)376-385
Number of pages10
JournalEuropean Review for Medical and Pharmacological Sciences
Volume16
Issue number3
Publication statusPublished - Mar 2012

Fingerprint

Gastrointestinal Diseases
Folic Acid
Health
Gastrointestinal Tract
Eye Diseases
Liver
Celiac Disease
Human Body
Nervous System
Biological Availability
Small Intestine
Psychiatry
Liver Diseases
Homeostasis

Keywords

  • 5-methyltetrahydrofolate (5-MTHF)
  • Celiac disease
  • Colorectal cancer
  • Folate
  • Folate homeostasis
  • Inflammatory bowel diseases
  • Liver cancer
  • Liver diseases

ASJC Scopus subject areas

  • Medicine(all)
  • Pharmacology (medical)

Cite this

Ponziani, F. R., Cazzato, I. A., Danese, S., Fagiuoli, S., Gionchetti, P., Annicchiarico, B. E., ... Gasbarrini, A. (2012). Folate in gastrointestinal health and disease. European Review for Medical and Pharmacological Sciences, 16(3), 376-385.

Folate in gastrointestinal health and disease. / Ponziani, F. R.; Cazzato, I. A.; Danese, S.; Fagiuoli, S.; Gionchetti, P.; Annicchiarico, B. E.; D'Aversa, F.; Gasbarrini, A.

In: European Review for Medical and Pharmacological Sciences, Vol. 16, No. 3, 03.2012, p. 376-385.

Research output: Contribution to journalArticle

Ponziani, FR, Cazzato, IA, Danese, S, Fagiuoli, S, Gionchetti, P, Annicchiarico, BE, D'Aversa, F & Gasbarrini, A 2012, 'Folate in gastrointestinal health and disease', European Review for Medical and Pharmacological Sciences, vol. 16, no. 3, pp. 376-385.
Ponziani FR, Cazzato IA, Danese S, Fagiuoli S, Gionchetti P, Annicchiarico BE et al. Folate in gastrointestinal health and disease. European Review for Medical and Pharmacological Sciences. 2012 Mar;16(3):376-385.
Ponziani, F. R. ; Cazzato, I. A. ; Danese, S. ; Fagiuoli, S. ; Gionchetti, P. ; Annicchiarico, B. E. ; D'Aversa, F. ; Gasbarrini, A. / Folate in gastrointestinal health and disease. In: European Review for Medical and Pharmacological Sciences. 2012 ; Vol. 16, No. 3. pp. 376-385.
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