TY - JOUR
T1 - Folate intake and folate serum levels in men and women from two European populations
T2 - The IMMIDIET project
AU - Pounis, George
AU - Di Castelnuovo, Augusto F.
AU - de Lorgeril, Michel
AU - Krogh, Vittorio
AU - Siani, Alfonso
AU - Arnout, Jozef
AU - Cappuccio, Francesco P.
AU - van Dongen, Martien
AU - Zappacosta, Bruno
AU - Donati, Maria Benedetta
AU - de Gaetano, Giovanni
AU - Iacoviello, Licia
AU - Arnout, Jef
AU - Buntinx, Frank
AU - Dagnelie, Pieter C.
AU - Lorgeril, Michel de
AU - Sian, Alfonso
AU - Dirckxc, Carla
AU - Castelnuovo, Augusto Di
AU - Dongen, Martien van
AU - Bonanni, Americo
AU - Rink, Pit
AU - Vohnout, Branislav
AU - Zito, Francesco
PY - 2014
Y1 - 2014
N2 - Objective: Folate status has been associated with neural tube defects and cerebrovascular disease. The aim of this study was to evaluate possible differences in folate status in two European Union countries and to assess their possible association with dietary patterns and/or other lifestyles. Methods: In the framework of the European Union-funded IMMIDIET Project, 1068 individuals (534 male-female pairs), ages 26 to 64 y, were enrolled in Italy and the United Kingdom. One-year-recall food frequency questionnaire was used to evaluate dietary intake. Reduced rank regression analysis was used to derive a dietary pattern better describing high dietary folate intake. Results: Of the total participants, 11.3% of the Italians and 45.1% of the British exceeded the optimal dietary folate intake of 400 μg/d (Recommended Dietary Allowance). Of the women, 66.7% and 22.1% of Italian and British women, respectively, all at childbearing age, had folate serum levels 0; P <0.001): 100 μg/d increase in dietary folate intake was associated with 13.8% and 10.5% increase in folate serum levels in the Italian and British population, respectively (for 100 μg/d increase eβ-coef = 1.138 and 1.105; P <0.001). Smoking habit was negatively but physical activity positively associated with folate serum levels (P <0.05). Conclusions: An inadequate dietary folate intake and subsequent serum levels were observed in the Italian participants. High consumption of food sources of folate was positively associated with folate serum levels, explaining a good proportion of its variability.
AB - Objective: Folate status has been associated with neural tube defects and cerebrovascular disease. The aim of this study was to evaluate possible differences in folate status in two European Union countries and to assess their possible association with dietary patterns and/or other lifestyles. Methods: In the framework of the European Union-funded IMMIDIET Project, 1068 individuals (534 male-female pairs), ages 26 to 64 y, were enrolled in Italy and the United Kingdom. One-year-recall food frequency questionnaire was used to evaluate dietary intake. Reduced rank regression analysis was used to derive a dietary pattern better describing high dietary folate intake. Results: Of the total participants, 11.3% of the Italians and 45.1% of the British exceeded the optimal dietary folate intake of 400 μg/d (Recommended Dietary Allowance). Of the women, 66.7% and 22.1% of Italian and British women, respectively, all at childbearing age, had folate serum levels 0; P <0.001): 100 μg/d increase in dietary folate intake was associated with 13.8% and 10.5% increase in folate serum levels in the Italian and British population, respectively (for 100 μg/d increase eβ-coef = 1.138 and 1.105; P <0.001). Smoking habit was negatively but physical activity positively associated with folate serum levels (P <0.05). Conclusions: An inadequate dietary folate intake and subsequent serum levels were observed in the Italian participants. High consumption of food sources of folate was positively associated with folate serum levels, explaining a good proportion of its variability.
KW - Cardiovascular disease
KW - Diet
KW - Dietary patterns
KW - Folate
KW - Folate status
KW - Neurovascular disease
UR - http://www.scopus.com/inward/record.url?scp=84903393560&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84903393560&partnerID=8YFLogxK
U2 - 10.1016/j.nut.2013.11.014
DO - 10.1016/j.nut.2013.11.014
M3 - Article
C2 - 24984999
AN - SCOPUS:84903393560
VL - 30
SP - 822
EP - 830
JO - Nutrition International
JF - Nutrition International
SN - 0899-9007
IS - 7-8
ER -