Folate intake and squamous-cell carcinoma of the oesophagus in Italian and Swiss men

C. Galeone, C. Pelucchi, F. Levi, E. Negri, R. Talamini, S. Franceschi, C. La Vecchia

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Background: Dietary folate has been inversely related to the risk of several cancers. However, studies on the role of dietary folate in oesophageal cancer are scanty. Patients and methods: Using data from a multicentric case-control study conducted in Italy and Switzerland between 1992 and 1999, we investigated the association between dietary folate intake and oesophageal squamous-cell carcinoma (OSCC) among 351 men with incident, histologically confirmed OSCC and 875 hospital controls admitted for acute, non-neoplastic conditions, unrelated to alcohol and smoking consumption. Intake of folate and other nutrients was computed from a validated food frequency questionnaire. Results: The multivariate odds ratios (ORs) of OSCC were 0.68 (95% confidence intervals, CI: 0.46 - 1.00) for the highest versus the lowest tertile of folate intake, and 0.84 (95% CI: 0.72 - 0.99) for an increment of folate intake equal to a standard deviation (98 μg/day). The inverse relation was somewhat stronger in strata of high methionine, vitamin B6 and alcohol intake, and did not vary substantially according to age and smoking habits. Conclusion: Dietary folate was inversely related to OSCC risk in this population with high alcohol consumption and infrequent use of supplements and multivitamins.

Original languageEnglish
Pages (from-to)521-525
Number of pages5
JournalAnnals of Oncology
Volume17
Issue number3
DOIs
Publication statusPublished - Mar 2006

Fingerprint

Folic Acid
Esophagus
Squamous Cell Carcinoma
Alcohol Drinking
Smoking
Food
Vitamin B 6
Esophageal Neoplasms
Switzerland
Methionine
Italy
Habits
Case-Control Studies
Odds Ratio
Alcohols
Confidence Intervals
Esophageal Squamous Cell Carcinoma
Population
Neoplasms

Keywords

  • Alcohol
  • Case-control study
  • Diet
  • Folate
  • Oesophageal squamous-cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

Cite this

Galeone, C., Pelucchi, C., Levi, F., Negri, E., Talamini, R., Franceschi, S., & La Vecchia, C. (2006). Folate intake and squamous-cell carcinoma of the oesophagus in Italian and Swiss men. Annals of Oncology, 17(3), 521-525. https://doi.org/10.1093/annonc/mdj107

Folate intake and squamous-cell carcinoma of the oesophagus in Italian and Swiss men. / Galeone, C.; Pelucchi, C.; Levi, F.; Negri, E.; Talamini, R.; Franceschi, S.; La Vecchia, C.

In: Annals of Oncology, Vol. 17, No. 3, 03.2006, p. 521-525.

Research output: Contribution to journalArticle

Galeone, C, Pelucchi, C, Levi, F, Negri, E, Talamini, R, Franceschi, S & La Vecchia, C 2006, 'Folate intake and squamous-cell carcinoma of the oesophagus in Italian and Swiss men', Annals of Oncology, vol. 17, no. 3, pp. 521-525. https://doi.org/10.1093/annonc/mdj107
Galeone C, Pelucchi C, Levi F, Negri E, Talamini R, Franceschi S et al. Folate intake and squamous-cell carcinoma of the oesophagus in Italian and Swiss men. Annals of Oncology. 2006 Mar;17(3):521-525. https://doi.org/10.1093/annonc/mdj107
Galeone, C. ; Pelucchi, C. ; Levi, F. ; Negri, E. ; Talamini, R. ; Franceschi, S. ; La Vecchia, C. / Folate intake and squamous-cell carcinoma of the oesophagus in Italian and Swiss men. In: Annals of Oncology. 2006 ; Vol. 17, No. 3. pp. 521-525.
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