Folate intake and squamous-cell carcinoma of the oesophagus in Italian and Swiss men

C. Galeone, C. Pelucchi, F. Levi, E. Negri, R. Talamini, S. Franceschi, C. La Vecchia

Research output: Contribution to journalArticlepeer-review


Background: Dietary folate has been inversely related to the risk of several cancers. However, studies on the role of dietary folate in oesophageal cancer are scanty. Patients and methods: Using data from a multicentric case-control study conducted in Italy and Switzerland between 1992 and 1999, we investigated the association between dietary folate intake and oesophageal squamous-cell carcinoma (OSCC) among 351 men with incident, histologically confirmed OSCC and 875 hospital controls admitted for acute, non-neoplastic conditions, unrelated to alcohol and smoking consumption. Intake of folate and other nutrients was computed from a validated food frequency questionnaire. Results: The multivariate odds ratios (ORs) of OSCC were 0.68 (95% confidence intervals, CI: 0.46 - 1.00) for the highest versus the lowest tertile of folate intake, and 0.84 (95% CI: 0.72 - 0.99) for an increment of folate intake equal to a standard deviation (98 μg/day). The inverse relation was somewhat stronger in strata of high methionine, vitamin B6 and alcohol intake, and did not vary substantially according to age and smoking habits. Conclusion: Dietary folate was inversely related to OSCC risk in this population with high alcohol consumption and infrequent use of supplements and multivitamins.

Original languageEnglish
Pages (from-to)521-525
Number of pages5
JournalAnnals of Oncology
Issue number3
Publication statusPublished - Mar 2006


  • Alcohol
  • Case-control study
  • Diet
  • Folate
  • Oesophageal squamous-cell carcinoma

ASJC Scopus subject areas

  • Oncology
  • Cancer Research


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