Abstract
Background: Dietary folate has been inversely related to the risk of several cancers. However, studies on the role of dietary folate in oesophageal cancer are scanty. Patients and methods: Using data from a multicentric case-control study conducted in Italy and Switzerland between 1992 and 1999, we investigated the association between dietary folate intake and oesophageal squamous-cell carcinoma (OSCC) among 351 men with incident, histologically confirmed OSCC and 875 hospital controls admitted for acute, non-neoplastic conditions, unrelated to alcohol and smoking consumption. Intake of folate and other nutrients was computed from a validated food frequency questionnaire. Results: The multivariate odds ratios (ORs) of OSCC were 0.68 (95% confidence intervals, CI: 0.46 - 1.00) for the highest versus the lowest tertile of folate intake, and 0.84 (95% CI: 0.72 - 0.99) for an increment of folate intake equal to a standard deviation (98 μg/day). The inverse relation was somewhat stronger in strata of high methionine, vitamin B6 and alcohol intake, and did not vary substantially according to age and smoking habits. Conclusion: Dietary folate was inversely related to OSCC risk in this population with high alcohol consumption and infrequent use of supplements and multivitamins.
| Original language | English |
|---|---|
| Pages (from-to) | 521-525 |
| Number of pages | 5 |
| Journal | Annals of Oncology |
| Volume | 17 |
| Issue number | 3 |
| DOIs | |
| Publication status | Published - Mar 2006 |
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Keywords
- Alcohol
- Case-control study
- Diet
- Folate
- Oesophageal squamous-cell carcinoma
ASJC Scopus subject areas
- Oncology
- Cancer Research
Cite this
Folate intake and squamous-cell carcinoma of the oesophagus in Italian and Swiss men. / Galeone, C.; Pelucchi, C.; Levi, F.; Negri, E.; Talamini, R.; Franceschi, S.; La Vecchia, C.
In: Annals of Oncology, Vol. 17, No. 3, 03.2006, p. 521-525.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Folate intake and squamous-cell carcinoma of the oesophagus in Italian and Swiss men
AU - Galeone, C.
AU - Pelucchi, C.
AU - Levi, F.
AU - Negri, E.
AU - Talamini, R.
AU - Franceschi, S.
AU - La Vecchia, C.
PY - 2006/3
Y1 - 2006/3
N2 - Background: Dietary folate has been inversely related to the risk of several cancers. However, studies on the role of dietary folate in oesophageal cancer are scanty. Patients and methods: Using data from a multicentric case-control study conducted in Italy and Switzerland between 1992 and 1999, we investigated the association between dietary folate intake and oesophageal squamous-cell carcinoma (OSCC) among 351 men with incident, histologically confirmed OSCC and 875 hospital controls admitted for acute, non-neoplastic conditions, unrelated to alcohol and smoking consumption. Intake of folate and other nutrients was computed from a validated food frequency questionnaire. Results: The multivariate odds ratios (ORs) of OSCC were 0.68 (95% confidence intervals, CI: 0.46 - 1.00) for the highest versus the lowest tertile of folate intake, and 0.84 (95% CI: 0.72 - 0.99) for an increment of folate intake equal to a standard deviation (98 μg/day). The inverse relation was somewhat stronger in strata of high methionine, vitamin B6 and alcohol intake, and did not vary substantially according to age and smoking habits. Conclusion: Dietary folate was inversely related to OSCC risk in this population with high alcohol consumption and infrequent use of supplements and multivitamins.
AB - Background: Dietary folate has been inversely related to the risk of several cancers. However, studies on the role of dietary folate in oesophageal cancer are scanty. Patients and methods: Using data from a multicentric case-control study conducted in Italy and Switzerland between 1992 and 1999, we investigated the association between dietary folate intake and oesophageal squamous-cell carcinoma (OSCC) among 351 men with incident, histologically confirmed OSCC and 875 hospital controls admitted for acute, non-neoplastic conditions, unrelated to alcohol and smoking consumption. Intake of folate and other nutrients was computed from a validated food frequency questionnaire. Results: The multivariate odds ratios (ORs) of OSCC were 0.68 (95% confidence intervals, CI: 0.46 - 1.00) for the highest versus the lowest tertile of folate intake, and 0.84 (95% CI: 0.72 - 0.99) for an increment of folate intake equal to a standard deviation (98 μg/day). The inverse relation was somewhat stronger in strata of high methionine, vitamin B6 and alcohol intake, and did not vary substantially according to age and smoking habits. Conclusion: Dietary folate was inversely related to OSCC risk in this population with high alcohol consumption and infrequent use of supplements and multivitamins.
KW - Alcohol
KW - Case-control study
KW - Diet
KW - Folate
KW - Oesophageal squamous-cell carcinoma
UR - http://www.scopus.com/inward/record.url?scp=33644693929&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=33644693929&partnerID=8YFLogxK
U2 - 10.1093/annonc/mdj107
DO - 10.1093/annonc/mdj107
M3 - Article
C2 - 16344275
AN - SCOPUS:33644693929
VL - 17
SP - 521
EP - 525
JO - Annals of Oncology
JF - Annals of Oncology
SN - 0923-7534
IS - 3
ER -