Folate status in type 2 diabetic patients with and without retinopathy

Giulia Malaguarnera, Caterina Gagliano, Salvatore Salomone, Maria Giordano, Claudio Bucolo, Antonino Pappalardo, Filippo Drago, Filippo Caraci, Teresio Avitabile, Massimo Motta

Research output: Contribution to journalArticlepeer-review


Background: Folate deficiency is associated with cardiovascular disease, megaloblastic anemia, and with hyperhomocysteinemia. This study has been undertaken to investigate the role of folate status during the progression of the diabetic retinopathy. Methods: We measured the plasma levels of homocysteine, folic acid, and red cell folate in 70 diabetic type 2 patients with nonproliferative diabetic retinopathy (NPDR), 65 with proliferative diabetic retinopathy (PDR), 96 without diabetic retinopathy, and 80 healthy subjects used as a control group. Results: We found higher plasma levels of homocysteine in the NPDR group compared to the control group (P

Original languageEnglish
Pages (from-to)1437-1442
Number of pages6
JournalClinical Ophthalmology
Publication statusPublished - Aug 7 2015


  • Diabetes mellitus
  • Homocysteine
  • Nonproliferative diabetic retinopathy
  • Proliferative diabetic retinopathy

ASJC Scopus subject areas

  • Ophthalmology


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