TY - JOUR
T1 - FOLFIRI as a second-line therapy in patients with docetaxel-pretreated gastric cancer
T2 - A historical cohort
AU - Maugeri-Saccà, Marcello
AU - Pizzuti, Laura
AU - Sergi, Domenico
AU - Barba, Maddalena
AU - Belli, Franca
AU - Fattoruso, Silvia Ileana
AU - Giannarelli, Diana
AU - Amodio, Antonella
AU - Boggia, Sara
AU - Vici, Patrizia
AU - Di Lauro, Luigi
PY - 2013
Y1 - 2013
N2 - Background: The role of second-line therapy in gastric cancer patients mostly stemmed from clinical trials with monochemotherapy carried out in Asian countries. Nevertheless, these results cannot be broadly generalized as molecular studies suggested the existence of different sets of deregulated gene networks correlated with ethnicity. In the present study, we investigated the activity and safety of FOLFIRI given as a second-line therapy in metastatic gastric or gastro-esophageal junction cancer patients who experienced disease progression on or after first-line docetaxel-containing chemotherapy. Methods. Patients with histologically confirmed metastatic gastric cancer who failed docetaxel-containing first-line therapy and who received FOLFIRI in second line were eligible for the study. Seventy patients treated at three Italian cancer centers between 2005 and 2012 entered the study. Patients received every 2 weeks irinotecan 180 mg/m§ssup§2§esup§ as 1 h infusion on day 1, folinic acid 100 mg/m§ssup§2§esup§ intravenously days 1-2, and fluorouracil as a 400 mg/m§ssup§2§esup§ bolus and then 600 mg/m§ssup§2§esup§ continuous infusion over 22 hours days 1-2. Results: We observed 1(1.4%) complete response, 15 (21.4%) partial response, for an overall response rate of 22.8% (95% confidence interval (CI): 13.4-32.3). Stable disease was recorded in 21 (30%) patients. Median progression-free survival and overall survival were 3.8 months (95% CI: 3.3-4.4) and 6.2 months (95% CI: 5.3-7.1), respectively. The treatment was well tolerated, as the most common G3-4 toxicities were neutropenia (28.5%) and diarrhea (14.5%). Conclusions: FOLFIRI appears an effective and safe treatment option for pretreated metastatic gastric cancer patients, and deserves further investigation in randomized clinical trials.
AB - Background: The role of second-line therapy in gastric cancer patients mostly stemmed from clinical trials with monochemotherapy carried out in Asian countries. Nevertheless, these results cannot be broadly generalized as molecular studies suggested the existence of different sets of deregulated gene networks correlated with ethnicity. In the present study, we investigated the activity and safety of FOLFIRI given as a second-line therapy in metastatic gastric or gastro-esophageal junction cancer patients who experienced disease progression on or after first-line docetaxel-containing chemotherapy. Methods. Patients with histologically confirmed metastatic gastric cancer who failed docetaxel-containing first-line therapy and who received FOLFIRI in second line were eligible for the study. Seventy patients treated at three Italian cancer centers between 2005 and 2012 entered the study. Patients received every 2 weeks irinotecan 180 mg/m§ssup§2§esup§ as 1 h infusion on day 1, folinic acid 100 mg/m§ssup§2§esup§ intravenously days 1-2, and fluorouracil as a 400 mg/m§ssup§2§esup§ bolus and then 600 mg/m§ssup§2§esup§ continuous infusion over 22 hours days 1-2. Results: We observed 1(1.4%) complete response, 15 (21.4%) partial response, for an overall response rate of 22.8% (95% confidence interval (CI): 13.4-32.3). Stable disease was recorded in 21 (30%) patients. Median progression-free survival and overall survival were 3.8 months (95% CI: 3.3-4.4) and 6.2 months (95% CI: 5.3-7.1), respectively. The treatment was well tolerated, as the most common G3-4 toxicities were neutropenia (28.5%) and diarrhea (14.5%). Conclusions: FOLFIRI appears an effective and safe treatment option for pretreated metastatic gastric cancer patients, and deserves further investigation in randomized clinical trials.
KW - FOLFIRI
KW - Gastric cancer
KW - Second-line chemotherapy
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U2 - 10.1186/1756-9966-32-67
DO - 10.1186/1756-9966-32-67
M3 - Article
C2 - 24330513
AN - SCOPUS:84883866029
VL - 32
JO - Journal of Experimental and Clinical Cancer Research
JF - Journal of Experimental and Clinical Cancer Research
SN - 0392-9078
IS - 1
M1 - 67
ER -