FOLFOX 2 regimen in heavily pretreated patients with advanced colorectal cancer

Gabriele Luppi, Francesca Zanelli, Antonio Di Stasi, Federica Bertolini, Micol Pifferi

Research output: Contribution to journalArticle

Abstract

Aims and background: To determine the efficacy and safety of the FOLFOX 2 regimen in patients with pretreated advanced colorectal cancer. Methods: In this single-arm phase II study, 28 patients with heavily pretreated advanced colorectal cancer received the following drug combination: oxaliplatin (100 mg/m 2 for 2 hrs on day 1), folinic acid (250 mg/m 2 for 2 hrs on day 1) and 5-fluorouracil (1500 mg/m 2 for 22 hrs continuous infusion on days 1 and 2) every 2 weeks (one cycle). The treatment was continued until unacceptable toxicity occurred or at most for 10 cycles. Results: Nine patients (32%) had a partial response and 5 (18%) stable disease, with a median duration of tumor control of 24 weeks (range, 8-44). The median survival of patients with a partial response or stable disease was 32 weeks (range, 12-52), whereas the median overall survival was 32 weeks (range, 872). A clinical benefit was achieved in 32% (9/21) of the patients. Severe (grade 3-4) non-hematological toxicity included diarrhea (1 patient), nausea/vomiting (7%) and peripheral neuropathy (1 patient). Severe hematological toxicities were rare (4%). Conclusions: Our phase II study confirmed the therapeutic effectiveness and safety of the FOLFOX 2 regimen in pretreated advanced colorectal cancer patients.

Original languageEnglish
Pages (from-to)270-272
Number of pages3
JournalTumori
Volume88
Issue number4
Publication statusPublished - Jul 2002

Keywords

  • Advanced colorectal cancer
  • Chemotherapy
  • Oxaliplatin

ASJC Scopus subject areas

  • Cancer Research

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    Luppi, G., Zanelli, F., Di Stasi, A., Bertolini, F., & Pifferi, M. (2002). FOLFOX 2 regimen in heavily pretreated patients with advanced colorectal cancer. Tumori, 88(4), 270-272.