Folic acid, vitamin B12, and homocysteine levels during fasting and after methionine load in patients with type 1 diabetes mellitus

A. Giannattasio, M. G. Calevo, G. Minniti, D. Gianotti, M. Cotellessa, F. Napoli, R. Lorini, G. D'Annunzio

Research output: Contribution to journalArticle

Abstract

Aims: To assess plasma concentrations of folic acid, vitamin B12, and total plasma homocysteine (tHCY) during fasting and after methionine load in young patients with Type 1 diabetes mellitus (T1 DM). Methods: We enrolled 41 young patients with T1 DM without any sign of microvascular complications and 123 healthy controls in a 1:3 case-control study. Fasting and post-methionine load (PML) tHCY, folic acid, and vitamin B12 levels were measured in both groups. Data regarding chronological age, metabolic control (assessed by mean values of glycated hemoglobin in the last 12 months) and disease duration were also recorded. Results: Fasting and PML tHCY levels were significantly lower in patients than in controls: 7.3±2.7 μmol/l vs 8.3±2.5 μmol/l (p=0.01), and 16.7±5.8 μmol/l vs 17.3±4.3 μmol/l (p=0.01), respectively. No correlation was found between fasting and PML tHCY levels and chronological age, disease duration, metabolic control, and insulin requirement. Patients had significantly higher vitamin B12 levels compared to controls: 767±318 pg/ml vs 628±236 pg/ml (p=0.003), while folic acid turned out to be lower in patients than in controls: 5.3±1.9 nmol/l vs7.5±2.6 nmol/l (p

Original languageEnglish
Pages (from-to)297-299
Number of pages3
JournalJournal of Endocrinological Investigation
Volume33
Issue number5
DOIs
Publication statusPublished - May 2010

Keywords

  • Folic acid
  • Homocysteine
  • Microangiopathy
  • Type 1 diabetes mellitus
  • Vitamin B12

ASJC Scopus subject areas

  • Endocrinology
  • Endocrinology, Diabetes and Metabolism

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