Folinic acid does improve 5-fluorouracil activity in vivo. Results of a phase III study comparing 5-fluorouracil to 5-fluorouracil and folinic acid in advanced colon cancer patients

E. Bobbio-Pallavicini, C. Porta, M. Moroni, A. Spaghi, I. Casagranda, G. Nastasi

Research output: Contribution to journalArticlepeer-review

Abstract

We report the results of a phase III trial in which we compared 5-fluorouracil (5-FU) to 5-FU and folinic acid (FA) in 150 previously untreated metastatic colon cancer patients. Patients were randomized in the ratio of 1:2 to receive 5-FU (370 mg/m2, i.v., for 5 days) in arm A or equidose 5-FU plus FA (200 mg/m2, i.v., for 5 days) for arm B, each cycle being repeated every 4 weeks. Five of 49 evaluable arm A patients (10.2%) and 31 of 97 arm B (31.9%) achieved a complete or partial response (p ≤ 0.01). Median survival time of arm A patients was 6 months (mean: 6.18), while it was 8 months (mean: 9.01) for arm B cases (p ≤ 0.05). In conclusion, our data indicate that FA can enhance 5-FU activity and that this combination is an effective palliative treatment for metastatic colon cancer patients.

Original languageEnglish
Pages (from-to)52-55
Number of pages4
JournalJournal of Chemotherapy
Volume5
Issue number1
Publication statusPublished - 1993

ASJC Scopus subject areas

  • Microbiology (medical)
  • Pharmacology (medical)

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