TY - JOUR
T1 - Follicular thyroid carcinoma with skull metastases
AU - Chiofalo, Maria Grazia
AU - Setola, Sergio Venanzio
AU - Di Gennaro, Francesca
AU - Fulciniti, Franco
AU - Catapano, Giuseppe
AU - Losito, Nunzia Simona
AU - Sandomenico, Fabio
AU - Catalano, Orlando
AU - Pezzullo, Luciano
PY - 2015
Y1 - 2015
N2 - Thyroid carcinoma with distant metastases at initial presentation, is uncommon. Skull metastases occur very rarely, with a reported incidence of 2.5-5.8%. Here we report two cases of follicular thyroid cancer with skull involvement, and describe the diagnostic and therapeutic approach to metastatic thyroid cancer. We present the cases of a 70-year-old female and a 74-year-old female who presented with painless, large slow-growing masses of the skull. The patients underwent surgical excision of the skull masses, which were histologically diagnosed as metastatic follicular thyroid cancer, and total thyroidectomy, which confirmed the diagnosis of follicular thyroid carcinoma. They were treated with radioiodine and suppressive levothyroxine, which achieved local control of the disease. Management of metastatic thyroid cancer, requires a multidisciplinary approach and multimodality treatment. Distant metastases should be surgically removed whenever possible. Initial aggressive treatment is crucial in the management of metastatic thyroid carcinoma, providing the best chance to prolong patient survival.
AB - Thyroid carcinoma with distant metastases at initial presentation, is uncommon. Skull metastases occur very rarely, with a reported incidence of 2.5-5.8%. Here we report two cases of follicular thyroid cancer with skull involvement, and describe the diagnostic and therapeutic approach to metastatic thyroid cancer. We present the cases of a 70-year-old female and a 74-year-old female who presented with painless, large slow-growing masses of the skull. The patients underwent surgical excision of the skull masses, which were histologically diagnosed as metastatic follicular thyroid cancer, and total thyroidectomy, which confirmed the diagnosis of follicular thyroid carcinoma. They were treated with radioiodine and suppressive levothyroxine, which achieved local control of the disease. Management of metastatic thyroid cancer, requires a multidisciplinary approach and multimodality treatment. Distant metastases should be surgically removed whenever possible. Initial aggressive treatment is crucial in the management of metastatic thyroid carcinoma, providing the best chance to prolong patient survival.
KW - Bone metastases
KW - Follicular thyroid cancer
KW - Skull metastases
UR - http://www.scopus.com/inward/record.url?scp=84929457653&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84929457653&partnerID=8YFLogxK
M3 - Article
C2 - 25797278
AN - SCOPUS:84929457653
VL - 62
SP - 363
EP - 369
JO - Endocrine Journal
JF - Endocrine Journal
SN - 0918-8959
IS - 4
ER -