Follikulotrope Mycosis fungoides bei einer Patientin mit Psoriasis unter Methotrexat-Therapie

Translated title of the contribution: Folliculotropic mycosis fungoides in a psoriatic patient under methotrexate treatment: Case reports

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Folliculotropic mycosis fungoides is a variant of mycosis fungoides with a worse prognosis than the classic form. It can be associated with follicular mucinosis. We report a case of folliculotropic mycosis fungoides developing in the months following methotrexate therapy in a psoriatic patient. This lymphoma did not regress after stopping the antipsoriatic treatment. There is a known relationship between the use of immunosuppressive therapies and the development of lymphoproliferative malignancies. However these lymphomas are mainly B-cell non-Hodgkin lymphomas associated with Epstein-Barr virus. In our patient the short period of time from the beginning of the immunosuppressive treatment to the occurrence of the T-cell lymphoma does not support a strong causal relationship between the drug intake and the development of mycosis fungoides. To the best of our knowledge, this is the first case of folliculotropic mycosis fungoides in a patient treated with methotrexate for psoriasis.

Original languageGerman
Pages (from-to)1068-1070
Number of pages3
JournalJDDG - Journal of the German Society of Dermatology
Volume7
Issue number12
DOIs
Publication statusPublished - Dec 2009

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Mycosis Fungoides
Methotrexate
Immunosuppressive Agents
Lymphoma
Follicular Mucinosis
Therapeutics
T-Cell Lymphoma
B-Cell Lymphoma
Human Herpesvirus 4
Psoriasis
Non-Hodgkin's Lymphoma
Pharmaceutical Preparations
Neoplasms

Keywords

  • Cutaneous T-cell lymphoma
  • Mycosis fungoides
  • Psoriasis

ASJC Scopus subject areas

  • Dermatology

Cite this

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title = "Follikulotrope Mycosis fungoides bei einer Patientin mit Psoriasis unter Methotrexat-Therapie",
abstract = "Folliculotropic mycosis fungoides is a variant of mycosis fungoides with a worse prognosis than the classic form. It can be associated with follicular mucinosis. We report a case of folliculotropic mycosis fungoides developing in the months following methotrexate therapy in a psoriatic patient. This lymphoma did not regress after stopping the antipsoriatic treatment. There is a known relationship between the use of immunosuppressive therapies and the development of lymphoproliferative malignancies. However these lymphomas are mainly B-cell non-Hodgkin lymphomas associated with Epstein-Barr virus. In our patient the short period of time from the beginning of the immunosuppressive treatment to the occurrence of the T-cell lymphoma does not support a strong causal relationship between the drug intake and the development of mycosis fungoides. To the best of our knowledge, this is the first case of folliculotropic mycosis fungoides in a patient treated with methotrexate for psoriasis.",
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AU - Grenzi, Laura

AU - Froio, Elisabetta

AU - Piana, Simonetta

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