Follow-up of a respiratory rate modulated pacemaker

M. Santomauro, S. Fazio, S. Ferraro, G. Maddalena, G. Papaccioli, C. Pappone, L. Sacca, M. Chiariello

Research output: Contribution to journalArticlepeer-review


The efficacy of 27 respiration sensitive rate modulated pacemakers (Biorate RDP-3, Biotec) implanted in the left pectoral area was evaluated every 3 months during a mean follow-up period of 29 months (range 10-50 months). Rate modulation function was unchanged other than for three patients in whom the auxiliary leads became displaced. Two implants lost ventricular sensing in this nonprogrammable model. In all but the three patients, Holter monitoring demonstrated pacing rate variation corresponding to daily activity. Stress test duration increased from 8.2 ± 1.5 minutes (in fixed rate VVI rate) to 12.83 ± 2.0 minutes (in the VVIR mode) (P <0.05). Right arm movement increased the pacing rate by 5 ± 3 beats/min (NS), while the left arm movement increase was 30 ± 5 beats/min (P <0.05). Mental, arithmetic, and nifedipine tests did not change the rate modulated pacing rate. The system responded to a change in respiratory rate by an increase in stimulation rate. A satisfactory response in sensitivity and velocity was present only with medium-high workloads. Interference with rate modulation occurred with movement of the arm ipsilateral to the implanted pulse generator.

Original languageEnglish
Pages (from-to)17-21
Number of pages5
JournalPACE - Pacing and Clinical Electrophysiology
Issue number1
Publication statusPublished - 1992

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine


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