Follow-up of high-grade squamous intra-epithelial lesions (H-SILs) in human immunodeficiency virus (HIV)-positive and human papillomavirus (HPV)-positive women. Analysis of risk factors

Antonio Frega, Alberto Biamonti, Luca Maranghi, Giuseppe Vetrano, Antonella Palazzo, Roberto Iacovelli, Roberto Corosu, Deborah French, Massimo Moscarini, Aldo Vecchione

Research output: Contribution to journalArticle

Abstract

Background: Human immunodeficiency virus (HIV)-positive women are at high risk of co-infection from human papillomavirus (HPV) and of developing squamous intraepithelial lesions of the cervix. Materials and Methods: From April 1997 to March 1999, 86 women, affected by high-grade squamous intra-epithelial lesions (H-SILs), were enrolled: 41 were HIV+ (CD4+ count >500/ml) and 45 were HIV-. The diagnosis of high-grade squamous intra-epithelial lesion (H-SIL) was established for each patient by Pap test, colposcopy and guided biopsy. For all samples, the HPV/DNA test was also performed by PCR. The patients' lesions and recurrence were treated by cone biopsy or large loop excision (LEEP). Annual controls were performed for 5 years. Results: A high rate of alcohol and drug use (60.7% vs. 31.4%; p=0.004; 80% vs. 27.5%; p

Original languageEnglish
Pages (from-to)3167-3170
Number of pages4
JournalAnticancer Research
Volume26
Issue number4 B
Publication statusPublished - Jul 2006

Keywords

  • Cervical lesions
  • H-SIL
  • HIV
  • HPV

ASJC Scopus subject areas

  • Cancer Research
  • Oncology

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