Follow-up of IgD-κ multiple myeloma by monitoring free light chains and total heavy chain IgD: A case report

Elena De Santis, Serena Masi, Iole Cordone, Francesco Pisani, Cecilia Zuppi, Fabrizio Mattei, Laura Conti, Giovanni Cigliana

Research output: Contribution to journalArticlepeer-review


Immunoglobulin (Ig)D-κ multiple myeloma (MM) is a rare neoplastic disease characterized by an aggressive and rapidly progressing course, which constitutes only a very small proportion of all MM cases. In the present report, the clinical case of a 51-year-old Caucasian woman diagnosed with IgD-κ MM is described. The patient underwent different chemotherapeutic treatments subsequently to a single autologous stem cell transplantation. Despite the inherent difficulty of monitoring IgD levels and performing serum immunofixation electrophoresis, the clinical outcome of the patient was almost uniquely monitored by measuring the levels of κ and λ free light chains (FLCs) and total heavy chain IgD. The data suggest the non-invasive potential and usefulness of FLCs evaluation for early detection of stringent complete remission, follow-up and early detection of disease relapse. In addition, this diagnostic procedure has successfully been employed for the therapeutic monitoring of the present patient, and may represent a very helpful, non-invasive tool for the follow-up of IgD myeloma patients without the requirement of serial bone marrow aspirate.

Original languageEnglish
Pages (from-to)1884-1888
Number of pages5
JournalOncology Letters
Issue number3
Publication statusPublished - Sep 1 2016


  • Auto-transplantation
  • Free light chains
  • Minimal residual disease
  • Multiple myeloma
  • Relapse
  • Total heavy chain IgD

ASJC Scopus subject areas

  • Oncology
  • Cancer Research

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