Follow-up of occupational asthma after removal from or diminution of exposure to the responsible agent: Relevance of the length of the interval from cessation of exposure

Luca Perfetti, André Cartier, Heberto Ghezzo, Denyse Gautrin, Jean Luc Malo

Research output: Contribution to journalArticle

Abstract

Study objective: We set the hypothesis that follow-up surveys of occupational asthma (OA) could now show better improvement in the asthmatic condition because of a more prolonged interval since removal from exposure than in previously reported studies. Patients/methods: Ninety-nine subjects with OA were assessed and were separated into two groups according to the duration of cessation of exposure: (1) group removed for ≤5 years: 48 subjects studied 8.9±2.2 years after cessation of exposure; (2) group removed for 1 (PC20) from a mean value of 1.5 to 3.7 mg/mL was documented (p20 at the follow-up visit was significantly higher in the group removed from exposure for >5 years than in the group removed for ≤5 years (16/33 vs 8/42; p=0.01). Stepwise logistic regression showed that follow-up PC20 could be predicted from baseline PC20 (p5 years show better prognostic figures than those reported in most previous studies. Comparison with the group removed for a shorter interval and the stepwise logistic regression analysis suggest that the longer duration of the interval from cessation of exposure appears to be a factor determining this difference.

Original languageEnglish
Pages (from-to)398-403
Number of pages6
JournalChest
Volume114
Issue number2
Publication statusPublished - 1998

Keywords

  • Asthma
  • Occupational asthma
  • Occupational diseases

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

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