Follow-up of patients with early breast cancer: Is it time to rewrite the story?

Fabio Puglisi, Caterina Fontanella, Gianmauro Numico, Valentina Sini, Laura Evangelista, Francesco Monetti, Stefania Gori, Lucia Del Mastro

Research output: Contribution to journalArticlepeer-review


The guidelines for follow-up in breast cancer survivors support only performance of periodic physical examination and annual mammography. However, medical oncologists and primary care physicians routinely recommend both blood tests and non-mammographic imaging tests in asymptomatic patients, leading to an increased anxiety related to false-positive results and higher medical expenses. Recently, advanced imaging technologies have improved sensitivity/specificity to detect metastatic lesions before symptoms arise. Considering the progress made in the treatment of metastatic disease and the rapid evolution of targeted therapy, that requires customization of the strategy according to molecular characteristics of the disease, patients could derive real benefit to early detection of disease recurrence. This hypothesis must be tested in a prospective clinical trial.

Original languageEnglish
Pages (from-to)130-141
Number of pages12
JournalCritical Reviews in Oncology/Hematology
Issue number2
Publication statusPublished - 2014


  • Early breast cancer
  • Follow-up
  • Surveillance
  • Survivorship care

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Geriatrics and Gerontology
  • Medicine(all)


Dive into the research topics of 'Follow-up of patients with early breast cancer: Is it time to rewrite the story?'. Together they form a unique fingerprint.

Cite this