Follow-up of residual shunt after patent foramen ovale closure

F. Orzan, W. Liboni, A. Bonzano, F. Molinari, M. Ribezzo, N. Rebaudengo, G. Grippi, E. Negri

Research output: Contribution to journalArticle


Objectives - Transesophageal echocardiography (TEE) is usually recommended in the evaluation of the patent foramen ovale (PFO). Our goal is to confirm the efficacy of contrast-enhanced transcranial Doppler (ce-TCD) in detecting residual significant right-to-left shunts (RLS) after PFO percutaneous closure. Materials and methods - Sixty-eight patients with a previous transient ischemic attack, stroke and a large PFO were investigated for residual RLS after percutaneous closure. Results - Assuming TEE as the gold standard, the sensitivity and negative predictive value of ce-TCD was 100%, whereas the specificity was 75.8% and the positive predictive value was 28%. Conclusions - ce-TCD appears to be the preferable technique to identify subjects with significant residual shunts after percutaneous closure of a PFO. In follow-up, if ce-TCD is negative, no further examination may be necessary; whereas if ce-TCD shows a residual shunt, it is advisable to perform a TEE investigation.

Original languageEnglish
Pages (from-to)257-261
Number of pages5
JournalActa Neurologica Scandinavica
Issue number4
Publication statusPublished - Oct 2010



  • patent foramen ovale
  • transcranial doppler
  • transesophageal echocardiography

ASJC Scopus subject areas

  • Clinical Neurology
  • Neurology

Cite this

Orzan, F., Liboni, W., Bonzano, A., Molinari, F., Ribezzo, M., Rebaudengo, N., Grippi, G., & Negri, E. (2010). Follow-up of residual shunt after patent foramen ovale closure. Acta Neurologica Scandinavica, 122(4), 257-261.