TY - JOUR
T1 - Follow-up of screening patients conservatively treated for cervical intraepithelial neoplasia grade 2-3
AU - Cristiani, Paolo
AU - De Nuzzo, Maria
AU - Costa, Silvano
AU - Prandi, Sonia
AU - Davi, Dino
AU - Turci, Marco
AU - Naldoni, Carlo
AU - Schincaglia, Patrizia
AU - Caprara, Licia
AU - Desiderio, Franco
AU - Manfredi, Marilena
AU - Farneti, Massimo
AU - Collina, Natalina
AU - Falcini, Fabio
AU - Dataro, Pier Giorgio
AU - de Bianchi, Priscilla Sassoli
AU - Bucchi, Lauro
PY - 2007/8
Y1 - 2007/8
N2 - Objectives: To evaluate the frequency and correlates of non-adherence to follow-up among patients conservatively treated for CIN2-3. Study design: Study population comprised 1560 patients aged 25-64 years from a screening programme in northern Italy. The regional standard protocol was used as a reference. Multinomial logistic regression analysis was used to estimate the odds ratio probability of a patient being lost to follow-up (no check-ups within 27 months of treatment) or incompletely followed-up (1-3 negative check-ups) versus having 4 negative check-ups. Results: Three hundred twenty-six patients (21%) were lost to follow-up, 678 (43%) were incompletely followed-up, 352 (23%) presented for 4 negative check-ups and 204 (13%) were diagnosed with persistent disease. The probability of no or incomplete follow-up was greater for patients who lived in the urban district, who were treated in private settings (versus screening centres), who exhibited a visibile squamocolumnar junction on pre-treatment colposcopy, who were treated with cold knife excision and local destructive therapy (versus loop diathermy excision), and whose surgical specimens had positive excision margins. Conclusions: Adherence to the reference protocol was poor. Factors involved in follow-up failures require greater clinical attention.
AB - Objectives: To evaluate the frequency and correlates of non-adherence to follow-up among patients conservatively treated for CIN2-3. Study design: Study population comprised 1560 patients aged 25-64 years from a screening programme in northern Italy. The regional standard protocol was used as a reference. Multinomial logistic regression analysis was used to estimate the odds ratio probability of a patient being lost to follow-up (no check-ups within 27 months of treatment) or incompletely followed-up (1-3 negative check-ups) versus having 4 negative check-ups. Results: Three hundred twenty-six patients (21%) were lost to follow-up, 678 (43%) were incompletely followed-up, 352 (23%) presented for 4 negative check-ups and 204 (13%) were diagnosed with persistent disease. The probability of no or incomplete follow-up was greater for patients who lived in the urban district, who were treated in private settings (versus screening centres), who exhibited a visibile squamocolumnar junction on pre-treatment colposcopy, who were treated with cold knife excision and local destructive therapy (versus loop diathermy excision), and whose surgical specimens had positive excision margins. Conclusions: Adherence to the reference protocol was poor. Factors involved in follow-up failures require greater clinical attention.
KW - Cervical intraepithelial neoplasia
KW - Follow-up
KW - Mass screening
KW - Treatment
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U2 - 10.1016/j.ejogrb.2006.05.020
DO - 10.1016/j.ejogrb.2006.05.020
M3 - Article
C2 - 16806647
AN - SCOPUS:34447504575
VL - 133
SP - 227
EP - 231
JO - European Journal of Obstetrics, Gynecology and Reproductive Biology
JF - European Journal of Obstetrics, Gynecology and Reproductive Biology
SN - 0028-2243
IS - 2
ER -