Follow-up of screening patients conservatively treated for cervical intraepithelial neoplasia grade 2-3

Paolo Cristiani, Maria De Nuzzo, Silvano Costa, Sonia Prandi, Dino Davi, Marco Turci, Carlo Naldoni, Patrizia Schincaglia, Licia Caprara, Franco Desiderio, Marilena Manfredi, Massimo Farneti, Natalina Collina, Fabio Falcini, Pier Giorgio Dataro, Priscilla Sassoli de Bianchi, Lauro Bucchi

Research output: Contribution to journalArticlepeer-review


Objectives: To evaluate the frequency and correlates of non-adherence to follow-up among patients conservatively treated for CIN2-3. Study design: Study population comprised 1560 patients aged 25-64 years from a screening programme in northern Italy. The regional standard protocol was used as a reference. Multinomial logistic regression analysis was used to estimate the odds ratio probability of a patient being lost to follow-up (no check-ups within 27 months of treatment) or incompletely followed-up (1-3 negative check-ups) versus having 4 negative check-ups. Results: Three hundred twenty-six patients (21%) were lost to follow-up, 678 (43%) were incompletely followed-up, 352 (23%) presented for 4 negative check-ups and 204 (13%) were diagnosed with persistent disease. The probability of no or incomplete follow-up was greater for patients who lived in the urban district, who were treated in private settings (versus screening centres), who exhibited a visibile squamocolumnar junction on pre-treatment colposcopy, who were treated with cold knife excision and local destructive therapy (versus loop diathermy excision), and whose surgical specimens had positive excision margins. Conclusions: Adherence to the reference protocol was poor. Factors involved in follow-up failures require greater clinical attention.

Original languageEnglish
Pages (from-to)227-231
Number of pages5
JournalEuropean Journal of Obstetrics and Gynecology and Reproductive Biology
Issue number2
Publication statusPublished - Aug 2007


  • Cervical intraepithelial neoplasia
  • Follow-up
  • Mass screening
  • Treatment

ASJC Scopus subject areas

  • Obstetrics and Gynaecology
  • Reproductive Medicine


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