Fondaparinux: Pharmacology and clinical experience in cardiovascular medicine

Vincenzo Toschi, M. Lettino

Research output: Contribution to journalArticlepeer-review

Abstract

Fondaparinux is a synthetic, five-saccharide chain, AT-dependent, anti-FXa agent. Studies showed that fondaparinux acts in prevention and treatment of venous thromboembolism and in ischemic heart disease, without significant bleeding risk. The drug inhibits thrombin generation, has long half-life and can be administered once-daily without laboratory monitoring. It may be used in HIT treatment.

Original languageEnglish
Pages (from-to)383-387
Number of pages5
JournalMini-Reviews in Medicinal Chemistry
Volume7
Issue number4
DOIs
Publication statusPublished - Apr 2007

Keywords

  • Antithrombotic
  • Factor Xa inhibitor
  • Fondaparinux
  • Heparin
  • Low molecular weight heparin

ASJC Scopus subject areas

  • Medicine (miscellaneous)
  • Chemistry(all)
  • Pharmacology

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