Food allergy: From the of loss of tolerance induced by exclusion diets to specific oral tolerance induction

Egidio Barbi, Irene Berti, Giorgio Longo

Research output: Contribution to journalArticlepeer-review

Abstract

The prevalence of food allergy and anaphylaxis in children is reported to be increasing in recent years. Evidence suggests that exposure to large doses of antigen might produce a suppression of the specific IgE response, so that the continuous contact with high doses of antigens favours the maintenance of tolerance In the same way loss of contact with allergen in children with specific IgE reactivity may favour a loss of tolerance with development of systemic reactions, while a progressive new contact with allergen may favour a specific tolerance induction. We hypothesize that widespread and uncontrolled use of elimination diets for atopic dermatitis may have played a role in the increase of allergy and anaphylaxis. Specific oral tolerance induction may be a possible therapeutic strategy. The article review food allergies caused by exclusion diet and also discuss recent patents related to the field.

Original languageEnglish
Pages (from-to)212-214
Number of pages3
JournalRecent Patents on Inflammation and Allergy Drug Discovery
Volume2
Issue number3
Publication statusPublished - 2008

Keywords

  • Exclusion diet
  • Food allergy
  • Immunological risk
  • Specific oral tolerance induction

ASJC Scopus subject areas

  • Immunology and Allergy
  • Drug Discovery

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