Food components and contaminants as (anti)androgenic molecules

Daniele Marcoccia, Marco Pellegrini, Marco Fiocchetti, Stefano Lorenzetti, Maria Marino

Research output: Contribution to journalReview article

9 Citations (Scopus)

Abstract

Androgens, the main male sex steroids, are the critical factors responsible for the development of the male phenotype during embryogenesis and for the achievement of sexual maturation and puberty. In adulthood, androgens remain essential for the maintenance of male reproductive function and behavior. Androgens, acting through the androgen receptor (AR), regulate male sexual differentiation during development, sperm production beginning from puberty, and maintenance of prostate homeostasis. Several substances present in the environment, now classified as endocrine disruptors (EDCs), strongly interfere with androgen actions in reproductive and non-reproductive tissues. EDCs are a heterogeneous group of xenobiotics which include synthetic chemicals used as industrial solvents/lubricants, plasticizers, additives, agrochemicals, pharmaceutical agents, and polyphenols of plant origin. These compounds are even present in the food as components (polyphenols) or food/water contaminants (pesticides, plasticizers used as food packaging) rendering the diet as the main route of exposure to EDCs for humans. Although huge amount of literature reports the (anti)estrogenic effects of different EDCs, relatively scarce information is available on the (anti)androgenic effects of EDCs. Here, the effects and mechanism of action of phytochemicals and pesticides and plasticizers as possible modulators of AR activities will be reviewed taking into account that insight derived from principles of endocrinology are required to estimate EDC consequences on endocrine deregulation and disease.

Original languageEnglish
Article number6
JournalGenes and Nutrition
Volume12
Issue number1
DOIs
Publication statusPublished - Feb 16 2017

Fingerprint

Plasticizers
Androgens
Food
Androgen Receptors
Polyphenols
Puberty
Pesticides
Maintenance
Food Packaging
Agrochemicals
Endocrine System Diseases
Lubricants
Endocrine Disruptors
Reproductive Behavior
Sexual Maturation
Sex Differentiation
Endocrinology
Phytochemicals
Xenobiotics
Embryonic Development

Keywords

  • Androgen
  • Androgen receptor
  • Endocrine disruptors
  • Pesticides
  • Plasticizers
  • Polyphenols

ASJC Scopus subject areas

  • Endocrinology, Diabetes and Metabolism
  • Genetics

Cite this

Food components and contaminants as (anti)androgenic molecules. / Marcoccia, Daniele; Pellegrini, Marco; Fiocchetti, Marco; Lorenzetti, Stefano; Marino, Maria.

In: Genes and Nutrition, Vol. 12, No. 1, 6, 16.02.2017.

Research output: Contribution to journalReview article

Marcoccia, Daniele ; Pellegrini, Marco ; Fiocchetti, Marco ; Lorenzetti, Stefano ; Marino, Maria. / Food components and contaminants as (anti)androgenic molecules. In: Genes and Nutrition. 2017 ; Vol. 12, No. 1.
@article{12f4fb1076d14c28ab83208688c6f8c4,
title = "Food components and contaminants as (anti)androgenic molecules",
abstract = "Androgens, the main male sex steroids, are the critical factors responsible for the development of the male phenotype during embryogenesis and for the achievement of sexual maturation and puberty. In adulthood, androgens remain essential for the maintenance of male reproductive function and behavior. Androgens, acting through the androgen receptor (AR), regulate male sexual differentiation during development, sperm production beginning from puberty, and maintenance of prostate homeostasis. Several substances present in the environment, now classified as endocrine disruptors (EDCs), strongly interfere with androgen actions in reproductive and non-reproductive tissues. EDCs are a heterogeneous group of xenobiotics which include synthetic chemicals used as industrial solvents/lubricants, plasticizers, additives, agrochemicals, pharmaceutical agents, and polyphenols of plant origin. These compounds are even present in the food as components (polyphenols) or food/water contaminants (pesticides, plasticizers used as food packaging) rendering the diet as the main route of exposure to EDCs for humans. Although huge amount of literature reports the (anti)estrogenic effects of different EDCs, relatively scarce information is available on the (anti)androgenic effects of EDCs. Here, the effects and mechanism of action of phytochemicals and pesticides and plasticizers as possible modulators of AR activities will be reviewed taking into account that insight derived from principles of endocrinology are required to estimate EDC consequences on endocrine deregulation and disease.",
keywords = "Androgen, Androgen receptor, Endocrine disruptors, Pesticides, Plasticizers, Polyphenols",
author = "Daniele Marcoccia and Marco Pellegrini and Marco Fiocchetti and Stefano Lorenzetti and Maria Marino",
year = "2017",
month = "2",
day = "16",
doi = "10.1186/s12263-017-0555-5",
language = "English",
volume = "12",
journal = "Genes and Nutrition",
issn = "1555-8932",
publisher = "Springer Verlag",
number = "1",

}

TY - JOUR

T1 - Food components and contaminants as (anti)androgenic molecules

AU - Marcoccia, Daniele

AU - Pellegrini, Marco

AU - Fiocchetti, Marco

AU - Lorenzetti, Stefano

AU - Marino, Maria

PY - 2017/2/16

Y1 - 2017/2/16

N2 - Androgens, the main male sex steroids, are the critical factors responsible for the development of the male phenotype during embryogenesis and for the achievement of sexual maturation and puberty. In adulthood, androgens remain essential for the maintenance of male reproductive function and behavior. Androgens, acting through the androgen receptor (AR), regulate male sexual differentiation during development, sperm production beginning from puberty, and maintenance of prostate homeostasis. Several substances present in the environment, now classified as endocrine disruptors (EDCs), strongly interfere with androgen actions in reproductive and non-reproductive tissues. EDCs are a heterogeneous group of xenobiotics which include synthetic chemicals used as industrial solvents/lubricants, plasticizers, additives, agrochemicals, pharmaceutical agents, and polyphenols of plant origin. These compounds are even present in the food as components (polyphenols) or food/water contaminants (pesticides, plasticizers used as food packaging) rendering the diet as the main route of exposure to EDCs for humans. Although huge amount of literature reports the (anti)estrogenic effects of different EDCs, relatively scarce information is available on the (anti)androgenic effects of EDCs. Here, the effects and mechanism of action of phytochemicals and pesticides and plasticizers as possible modulators of AR activities will be reviewed taking into account that insight derived from principles of endocrinology are required to estimate EDC consequences on endocrine deregulation and disease.

AB - Androgens, the main male sex steroids, are the critical factors responsible for the development of the male phenotype during embryogenesis and for the achievement of sexual maturation and puberty. In adulthood, androgens remain essential for the maintenance of male reproductive function and behavior. Androgens, acting through the androgen receptor (AR), regulate male sexual differentiation during development, sperm production beginning from puberty, and maintenance of prostate homeostasis. Several substances present in the environment, now classified as endocrine disruptors (EDCs), strongly interfere with androgen actions in reproductive and non-reproductive tissues. EDCs are a heterogeneous group of xenobiotics which include synthetic chemicals used as industrial solvents/lubricants, plasticizers, additives, agrochemicals, pharmaceutical agents, and polyphenols of plant origin. These compounds are even present in the food as components (polyphenols) or food/water contaminants (pesticides, plasticizers used as food packaging) rendering the diet as the main route of exposure to EDCs for humans. Although huge amount of literature reports the (anti)estrogenic effects of different EDCs, relatively scarce information is available on the (anti)androgenic effects of EDCs. Here, the effects and mechanism of action of phytochemicals and pesticides and plasticizers as possible modulators of AR activities will be reviewed taking into account that insight derived from principles of endocrinology are required to estimate EDC consequences on endocrine deregulation and disease.

KW - Androgen

KW - Androgen receptor

KW - Endocrine disruptors

KW - Pesticides

KW - Plasticizers

KW - Polyphenols

UR - http://www.scopus.com/inward/record.url?scp=85029844247&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85029844247&partnerID=8YFLogxK

U2 - 10.1186/s12263-017-0555-5

DO - 10.1186/s12263-017-0555-5

M3 - Review article

AN - SCOPUS:85029844247

VL - 12

JO - Genes and Nutrition

JF - Genes and Nutrition

SN - 1555-8932

IS - 1

M1 - 6

ER -