Abstract
Objective: To systematically review all the available evidence from prospective cohort studies that investigated the association between consumption of food groups and the occurrence of age-related macular degeneration (AMD). Methods: We conducted an electronic literature search through MedLine, Embase, Google Scholar, Web of Science, and bibliographies of retrieved articles up to January, 2018. Studies were included if they analysed prospectively the association between consumption of food groups and AMD. Results: At the end of the selection process, 26 articles were included in the meta-analysis, for a total of 211,676 subjects and 7154 cases of AMD. By comparing the highest vs. the lowest consumption, pooled analyses showed no significant association with AMD for vegetables, fruit, nuts, grains, dairy products, as well as dietary fats such as oils, butter and margarine. Fish determined a significant (p < 0.05) reduction of risk for total AMD (RR 0.82 95% CI 0.75–0.90), as well as for both early (RR 0.84 95% CI 0.73–0.97), and late (RR 0.79 95% CI 0.70–0.90) AMD. On the other hand, high meat consumption was associated with a significant increased risk of early (RR 1.17 95% CI 1.02–1.34), but not late AMD. Finally, a significant increased risk of AMD for the highest consumption of alcohol (RR 1.20 95% CI 1.04–1.39) was reported. Conclusions: The results of the present meta-analysis show a significant 18% reduced risk for fish and a 20% increased risk for alcohol consumption. In addition, an increased risk was observed for meat, but only in the subgroup of early AMD.
| Original language | English |
|---|---|
| Pages (from-to) | 1-21 |
| Number of pages | 21 |
| Journal | European Journal of Nutrition |
| DOIs | |
| Publication status | E-pub ahead of print - Jul 5 2018 |
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Keywords
- Diet
- Food
- Macular degeneration
- Nutrition
ASJC Scopus subject areas
- Medicine (miscellaneous)
- Nutrition and Dietetics
Cite this
Food groups and risk of age-related macular degeneration : a systematic review with meta-analysis. / Dinu, Monica; Pagliai, Giuditta; Casini, Alessandro; Sofi, Francesco.
In: European Journal of Nutrition, 05.07.2018, p. 1-21.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Food groups and risk of age-related macular degeneration
T2 - a systematic review with meta-analysis
AU - Dinu, Monica
AU - Pagliai, Giuditta
AU - Casini, Alessandro
AU - Sofi, Francesco
PY - 2018/7/5
Y1 - 2018/7/5
N2 - Objective: To systematically review all the available evidence from prospective cohort studies that investigated the association between consumption of food groups and the occurrence of age-related macular degeneration (AMD). Methods: We conducted an electronic literature search through MedLine, Embase, Google Scholar, Web of Science, and bibliographies of retrieved articles up to January, 2018. Studies were included if they analysed prospectively the association between consumption of food groups and AMD. Results: At the end of the selection process, 26 articles were included in the meta-analysis, for a total of 211,676 subjects and 7154 cases of AMD. By comparing the highest vs. the lowest consumption, pooled analyses showed no significant association with AMD for vegetables, fruit, nuts, grains, dairy products, as well as dietary fats such as oils, butter and margarine. Fish determined a significant (p < 0.05) reduction of risk for total AMD (RR 0.82 95% CI 0.75–0.90), as well as for both early (RR 0.84 95% CI 0.73–0.97), and late (RR 0.79 95% CI 0.70–0.90) AMD. On the other hand, high meat consumption was associated with a significant increased risk of early (RR 1.17 95% CI 1.02–1.34), but not late AMD. Finally, a significant increased risk of AMD for the highest consumption of alcohol (RR 1.20 95% CI 1.04–1.39) was reported. Conclusions: The results of the present meta-analysis show a significant 18% reduced risk for fish and a 20% increased risk for alcohol consumption. In addition, an increased risk was observed for meat, but only in the subgroup of early AMD.
AB - Objective: To systematically review all the available evidence from prospective cohort studies that investigated the association between consumption of food groups and the occurrence of age-related macular degeneration (AMD). Methods: We conducted an electronic literature search through MedLine, Embase, Google Scholar, Web of Science, and bibliographies of retrieved articles up to January, 2018. Studies were included if they analysed prospectively the association between consumption of food groups and AMD. Results: At the end of the selection process, 26 articles were included in the meta-analysis, for a total of 211,676 subjects and 7154 cases of AMD. By comparing the highest vs. the lowest consumption, pooled analyses showed no significant association with AMD for vegetables, fruit, nuts, grains, dairy products, as well as dietary fats such as oils, butter and margarine. Fish determined a significant (p < 0.05) reduction of risk for total AMD (RR 0.82 95% CI 0.75–0.90), as well as for both early (RR 0.84 95% CI 0.73–0.97), and late (RR 0.79 95% CI 0.70–0.90) AMD. On the other hand, high meat consumption was associated with a significant increased risk of early (RR 1.17 95% CI 1.02–1.34), but not late AMD. Finally, a significant increased risk of AMD for the highest consumption of alcohol (RR 1.20 95% CI 1.04–1.39) was reported. Conclusions: The results of the present meta-analysis show a significant 18% reduced risk for fish and a 20% increased risk for alcohol consumption. In addition, an increased risk was observed for meat, but only in the subgroup of early AMD.
KW - Diet
KW - Food
KW - Macular degeneration
KW - Nutrition
UR - http://www.scopus.com/inward/record.url?scp=85049562473&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=85049562473&partnerID=8YFLogxK
U2 - 10.1007/s00394-018-1771-5
DO - 10.1007/s00394-018-1771-5
M3 - Article
AN - SCOPUS:85049562473
SP - 1
EP - 21
JO - European Journal of Nutrition
JF - European Journal of Nutrition
SN - 1436-6207
ER -