Food of animal origin and risk of non-Hodgkin lymphoma and multiple myeloma: A review of the literature and meta-analysis

Saverio Caini, Giovanna Masala, Patrizia Gnagnarella, Ilaria Ermini, William Russell-Edu, Domenico Palli, Sara Gandini

Research output: Contribution to journalArticle

Abstract

Background: Several studies investigated whether the consumption of foods of animal origin affects the risk of haematological malignancies, with conflicting results. To help clarify this issue, we performed a meta-analysis of observational studies published until November 2014 that investigated the association between the consumption of foods of animal origin (red, processed and white meat, fish and seafood, dairy products and eggs) and the risk of non-Hodgkin lymphoma and its major subtypes and multiple myeloma among adults. Methods: We calculated summary relative risks (SRR) and 95% confidence intervals (95% CI) by using random effect models with maximum likelihood estimation. Results: Overall, 16,525 non-Hodgkin lymphoma and 3665 multiple myeloma cases from thirty-three independent studies were included. We found an association between consumption of red meat and the risk of non-Hodgkin lymphoma (SRR 1.22, 95% CI 1.03-1.44, I2 = 35%). The consumption of fish and seafood was inversely associated with the risk of multiple myeloma (SRR 0.71, 95% CI 0.51-1.00, I2 = 82%), although the between-studies heterogeneity was high. Finally, the consumption of dairy products was positively associated, with borderline significance, with the risk of non-Hodgkin lymphoma (SRR 1.26, 95% CI 0.99-1.60, I2 = 49%). Conclusions: Foods of animal origin likely play a role in the aetiology of non-Hodgkin lymphoma and multiple myeloma, with red meat and dairy tending to increase the risk, and fish that tends to decrease it. Our findings reinforce the recommendations to reduce the consumption of red meat by replacing it with vegetables, legumes and fish.

Original languageEnglish
Pages (from-to)16-24
Number of pages9
JournalCritical Reviews in Oncology/Hematology
Volume100
DOIs
Publication statusPublished - Apr 1 2016

Fingerprint

Multiple Myeloma
Non-Hodgkin's Lymphoma
Meta-Analysis
Food
Fishes
Confidence Intervals
Seafood
Dairy Products
Hematologic Neoplasms
Fabaceae
Vegetables
Meat
Eggs
Observational Studies

Keywords

  • Foods of animal origin
  • Meta-analysis
  • Myeloma
  • Non-Hodgkin lymphoma

ASJC Scopus subject areas

  • Oncology
  • Hematology
  • Geriatrics and Gerontology

Cite this

Food of animal origin and risk of non-Hodgkin lymphoma and multiple myeloma : A review of the literature and meta-analysis. / Caini, Saverio; Masala, Giovanna; Gnagnarella, Patrizia; Ermini, Ilaria; Russell-Edu, William; Palli, Domenico; Gandini, Sara.

In: Critical Reviews in Oncology/Hematology, Vol. 100, 01.04.2016, p. 16-24.

Research output: Contribution to journalArticle

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abstract = "Background: Several studies investigated whether the consumption of foods of animal origin affects the risk of haematological malignancies, with conflicting results. To help clarify this issue, we performed a meta-analysis of observational studies published until November 2014 that investigated the association between the consumption of foods of animal origin (red, processed and white meat, fish and seafood, dairy products and eggs) and the risk of non-Hodgkin lymphoma and its major subtypes and multiple myeloma among adults. Methods: We calculated summary relative risks (SRR) and 95{\%} confidence intervals (95{\%} CI) by using random effect models with maximum likelihood estimation. Results: Overall, 16,525 non-Hodgkin lymphoma and 3665 multiple myeloma cases from thirty-three independent studies were included. We found an association between consumption of red meat and the risk of non-Hodgkin lymphoma (SRR 1.22, 95{\%} CI 1.03-1.44, I2 = 35{\%}). The consumption of fish and seafood was inversely associated with the risk of multiple myeloma (SRR 0.71, 95{\%} CI 0.51-1.00, I2 = 82{\%}), although the between-studies heterogeneity was high. Finally, the consumption of dairy products was positively associated, with borderline significance, with the risk of non-Hodgkin lymphoma (SRR 1.26, 95{\%} CI 0.99-1.60, I2 = 49{\%}). Conclusions: Foods of animal origin likely play a role in the aetiology of non-Hodgkin lymphoma and multiple myeloma, with red meat and dairy tending to increase the risk, and fish that tends to decrease it. Our findings reinforce the recommendations to reduce the consumption of red meat by replacing it with vegetables, legumes and fish.",
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AU - Caini, Saverio

AU - Masala, Giovanna

AU - Gnagnarella, Patrizia

AU - Ermini, Ilaria

AU - Russell-Edu, William

AU - Palli, Domenico

AU - Gandini, Sara

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N2 - Background: Several studies investigated whether the consumption of foods of animal origin affects the risk of haematological malignancies, with conflicting results. To help clarify this issue, we performed a meta-analysis of observational studies published until November 2014 that investigated the association between the consumption of foods of animal origin (red, processed and white meat, fish and seafood, dairy products and eggs) and the risk of non-Hodgkin lymphoma and its major subtypes and multiple myeloma among adults. Methods: We calculated summary relative risks (SRR) and 95% confidence intervals (95% CI) by using random effect models with maximum likelihood estimation. Results: Overall, 16,525 non-Hodgkin lymphoma and 3665 multiple myeloma cases from thirty-three independent studies were included. We found an association between consumption of red meat and the risk of non-Hodgkin lymphoma (SRR 1.22, 95% CI 1.03-1.44, I2 = 35%). The consumption of fish and seafood was inversely associated with the risk of multiple myeloma (SRR 0.71, 95% CI 0.51-1.00, I2 = 82%), although the between-studies heterogeneity was high. Finally, the consumption of dairy products was positively associated, with borderline significance, with the risk of non-Hodgkin lymphoma (SRR 1.26, 95% CI 0.99-1.60, I2 = 49%). Conclusions: Foods of animal origin likely play a role in the aetiology of non-Hodgkin lymphoma and multiple myeloma, with red meat and dairy tending to increase the risk, and fish that tends to decrease it. Our findings reinforce the recommendations to reduce the consumption of red meat by replacing it with vegetables, legumes and fish.

AB - Background: Several studies investigated whether the consumption of foods of animal origin affects the risk of haematological malignancies, with conflicting results. To help clarify this issue, we performed a meta-analysis of observational studies published until November 2014 that investigated the association between the consumption of foods of animal origin (red, processed and white meat, fish and seafood, dairy products and eggs) and the risk of non-Hodgkin lymphoma and its major subtypes and multiple myeloma among adults. Methods: We calculated summary relative risks (SRR) and 95% confidence intervals (95% CI) by using random effect models with maximum likelihood estimation. Results: Overall, 16,525 non-Hodgkin lymphoma and 3665 multiple myeloma cases from thirty-three independent studies were included. We found an association between consumption of red meat and the risk of non-Hodgkin lymphoma (SRR 1.22, 95% CI 1.03-1.44, I2 = 35%). The consumption of fish and seafood was inversely associated with the risk of multiple myeloma (SRR 0.71, 95% CI 0.51-1.00, I2 = 82%), although the between-studies heterogeneity was high. Finally, the consumption of dairy products was positively associated, with borderline significance, with the risk of non-Hodgkin lymphoma (SRR 1.26, 95% CI 0.99-1.60, I2 = 49%). Conclusions: Foods of animal origin likely play a role in the aetiology of non-Hodgkin lymphoma and multiple myeloma, with red meat and dairy tending to increase the risk, and fish that tends to decrease it. Our findings reinforce the recommendations to reduce the consumption of red meat by replacing it with vegetables, legumes and fish.

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