Food restriction in female Wistar rats. I. survival characteristics, membrane microviscosity and proliferative response in lymphocytes

C. Pieri, R. Recchioni, F. Moroni, F. Marcheselli, M. Falasca, L. Piantanelli

Research output: Contribution to journalArticle

Abstract

The effect of food restriction on the survival characteristics, membrane microviscosity and proliferative response in lymphocytes of female Wistar undernourished rats has been evaluated. Diet restriction was applied starting from the age of 3.5 months by feeding the animals on an every-other-day schedule (EOD). Diet restricted animals showed an increase of both mean, median and maximal life span as compared to the rats fed ad libitum (AL). Analyzing the survival curves by a parametric model, it emerged that undernutrition increased the individual resistance to environmental insults. In particular, it could be speculated that the positive influence was more pronounced in individuals with the lowest physiological capacities. The membrane microviscosity of lymphocytes was lower in EOD animals as compared to the AL ones even if one assumes a decrease in body temperature of 1-2°C in EOD groups. The improvement of membrane microviscosity due to diet restriction may in part explain the improvement of proliferative response of lymphocytes from EOD groups.

Original languageEnglish
Pages (from-to)99-108
Number of pages10
JournalArchives of Gerontology and Geriatrics
Volume11
Issue number2
DOIs
Publication statusPublished - 1990

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Wistar Rats
Appointments and Schedules
animal
Lymphocytes
food
Food
Membranes
Diet
life-span
Group
Body Temperature
Malnutrition

Keywords

  • Diet restriction
  • Lymphocytes
  • Membrane microviscosity
  • Survival kinetics

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

Cite this

Food restriction in female Wistar rats. I. survival characteristics, membrane microviscosity and proliferative response in lymphocytes. / Pieri, C.; Recchioni, R.; Moroni, F.; Marcheselli, F.; Falasca, M.; Piantanelli, L.

In: Archives of Gerontology and Geriatrics, Vol. 11, No. 2, 1990, p. 99-108.

Research output: Contribution to journalArticle

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AU - Piantanelli, L.

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