Abstract
The effect of diet restriction, applied on an every-other-day schedule from 3.5 months of age on, has been investigated on the β-adrenoceptor density in the cerebellum and in the splenic lymphocytes of old female Wistar rats. Comparing animals 6 months and 24 months old fed ad libitum, a 75% age-dependent reduction in specific binding of the agonist dihydroalprenolol was observed in cerebellar membrane preparations, while the β-adrenoceptor density of lymphocytes remained unaltered. Diet restriction induced a partial recovery of the age-related decrease of this parameter in the cerebellum without affecting the receptor density of lymphocytes. Present results suggest that undernutrition delays the appearance of those alterations related to aging.
| Original language | English |
|---|---|
| Pages (from-to) | 109-115 |
| Number of pages | 7 |
| Journal | Archives of Gerontology and Geriatrics |
| Volume | 11 |
| Issue number | 2 |
| DOIs | |
| Publication status | Published - 1990 |
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Keywords
- Cerebellum
- Lymphocytes
- Undernutrition
- β-Adrenoceptors
ASJC Scopus subject areas
- Ageing
- Medicine(all)
Cite this
Food restriction in female Wistar rats. II. β-adrenoceptor density in the cerebellum and in the splenic lymphocytes. / Pieri, C.; Moroni, F.; Marcheselli, F.; Falasca, M.; Recchioni, R.
In: Archives of Gerontology and Geriatrics, Vol. 11, No. 2, 1990, p. 109-115.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Food restriction in female Wistar rats. II. β-adrenoceptor density in the cerebellum and in the splenic lymphocytes
AU - Pieri, C.
AU - Moroni, F.
AU - Marcheselli, F.
AU - Falasca, M.
AU - Recchioni, R.
PY - 1990
Y1 - 1990
N2 - The effect of diet restriction, applied on an every-other-day schedule from 3.5 months of age on, has been investigated on the β-adrenoceptor density in the cerebellum and in the splenic lymphocytes of old female Wistar rats. Comparing animals 6 months and 24 months old fed ad libitum, a 75% age-dependent reduction in specific binding of the agonist dihydroalprenolol was observed in cerebellar membrane preparations, while the β-adrenoceptor density of lymphocytes remained unaltered. Diet restriction induced a partial recovery of the age-related decrease of this parameter in the cerebellum without affecting the receptor density of lymphocytes. Present results suggest that undernutrition delays the appearance of those alterations related to aging.
AB - The effect of diet restriction, applied on an every-other-day schedule from 3.5 months of age on, has been investigated on the β-adrenoceptor density in the cerebellum and in the splenic lymphocytes of old female Wistar rats. Comparing animals 6 months and 24 months old fed ad libitum, a 75% age-dependent reduction in specific binding of the agonist dihydroalprenolol was observed in cerebellar membrane preparations, while the β-adrenoceptor density of lymphocytes remained unaltered. Diet restriction induced a partial recovery of the age-related decrease of this parameter in the cerebellum without affecting the receptor density of lymphocytes. Present results suggest that undernutrition delays the appearance of those alterations related to aging.
KW - Cerebellum
KW - Lymphocytes
KW - Undernutrition
KW - β-Adrenoceptors
UR - http://www.scopus.com/inward/record.url?scp=0024994301&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0024994301&partnerID=8YFLogxK
U2 - 10.1016/0167-4943(90)90002-N
DO - 10.1016/0167-4943(90)90002-N
M3 - Article
C2 - 15374481
AN - SCOPUS:0024994301
VL - 11
SP - 109
EP - 115
JO - Archives of Gerontology and Geriatrics
JF - Archives of Gerontology and Geriatrics
SN - 0167-4943
IS - 2
ER -