Food restriction in female Wistar rats. II. β-adrenoceptor density in the cerebellum and in the splenic lymphocytes

C. Pieri, F. Moroni, F. Marcheselli, M. Falasca, R. Recchioni

Research output: Contribution to journalArticlepeer-review

Abstract

The effect of diet restriction, applied on an every-other-day schedule from 3.5 months of age on, has been investigated on the β-adrenoceptor density in the cerebellum and in the splenic lymphocytes of old female Wistar rats. Comparing animals 6 months and 24 months old fed ad libitum, a 75% age-dependent reduction in specific binding of the agonist dihydroalprenolol was observed in cerebellar membrane preparations, while the β-adrenoceptor density of lymphocytes remained unaltered. Diet restriction induced a partial recovery of the age-related decrease of this parameter in the cerebellum without affecting the receptor density of lymphocytes. Present results suggest that undernutrition delays the appearance of those alterations related to aging.

Original languageEnglish
Pages (from-to)109-115
Number of pages7
JournalArchives of Gerontology and Geriatrics
Volume11
Issue number2
DOIs
Publication statusPublished - 1990

Keywords

  • Cerebellum
  • Lymphocytes
  • Undernutrition
  • β-Adrenoceptors

ASJC Scopus subject areas

  • Ageing
  • Medicine(all)

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