Abstract
Background: It is unknown whether diets with a high dietary total antioxidant capacity (TAC) can modify oxidative stress, low-grade inflammation, or liver dysfunction, all of which are risk factors for type 2 diabetes and cardiovascular disease. Objective: We studied the effect of high- and low-TAC (HT and LT, respectively) diets on markers of antioxidant status, systemic inflammation, and liver dysfunction. Design: In a crossover intervention, 33 healthy adults (19 men, 14 women) received the HT and LT diets for 2 wk each. Dietary habits were checked with a 3-d food record during both diet periods and the washout period. Results: Fruit and vegetable, macronutrient, dietary fiber, and alcohol intakes did not differ significantly between the 2 diets, whereas dietary TAC, α-tocopherol, and ascorbic acid were significantly (P <0.001) higher during the HT diet. Plasma α-tocopherol rose during the HT and decreased during the LT diet (P <0.02 for difference) without changes in markers of oxidative stress except plasma malondialdehyde, which decreased unexpectedly during the LT diet (P <0.05). Plasma high-sensitivity C-reactive protein, alanine aminotransferase, gamma-glutamyltranspeptidase, and alkaline phosphatase concentrations decreased during the HT compared with the LT diet (mean ± SEM for pre-post changes: -0.72 ± 0.37 compared with 1.05 ± 0.60 mg/L, P <0.01; -1.73 ± 1.02 compared with 2.33 ± 2.58 U/L, P <0.01; -2.12 ± 1.45 compared with 5.15 ± 2.98 U/L, P <0.05; and 1.36 ± 1.34 compared with 5.06 ± 2.00 U/L, P <0.01, respectively). Conclusion: Selecting foods according to their TAC markedly affects antioxidant intake and modulates hepatic contribution to systemic inflammation without affecting traditional markers of antioxidant status.
| Original language | English |
|---|---|
| Pages (from-to) | 1290-1297 |
| Number of pages | 8 |
| Journal | American Journal of Clinical Nutrition |
| Volume | 87 |
| Issue number | 5 |
| Publication status | Published - May 1 2008 |
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ASJC Scopus subject areas
- Food Science
- Medicine (miscellaneous)
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Food selection based on total antioxidant capacity can modify antioxidant intake, systemic inflammation, and liver function without altering markers of oxidative stress. / Valtueña, Silvia; Pellegrini, Nicoletta; Franzini, Laura; Bianchi, Marta A.; Ardigò, Diego; Del Rio, Daniele; Piatti, PierMarco; Scazzina, Francesca; Zavaroni, Ivana; Brighenti, Furio.
In: American Journal of Clinical Nutrition, Vol. 87, No. 5, 01.05.2008, p. 1290-1297.Research output: Contribution to journal › Article
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TY - JOUR
T1 - Food selection based on total antioxidant capacity can modify antioxidant intake, systemic inflammation, and liver function without altering markers of oxidative stress
AU - Valtueña, Silvia
AU - Pellegrini, Nicoletta
AU - Franzini, Laura
AU - Bianchi, Marta A.
AU - Ardigò, Diego
AU - Del Rio, Daniele
AU - Piatti, PierMarco
AU - Scazzina, Francesca
AU - Zavaroni, Ivana
AU - Brighenti, Furio
PY - 2008/5/1
Y1 - 2008/5/1
N2 - Background: It is unknown whether diets with a high dietary total antioxidant capacity (TAC) can modify oxidative stress, low-grade inflammation, or liver dysfunction, all of which are risk factors for type 2 diabetes and cardiovascular disease. Objective: We studied the effect of high- and low-TAC (HT and LT, respectively) diets on markers of antioxidant status, systemic inflammation, and liver dysfunction. Design: In a crossover intervention, 33 healthy adults (19 men, 14 women) received the HT and LT diets for 2 wk each. Dietary habits were checked with a 3-d food record during both diet periods and the washout period. Results: Fruit and vegetable, macronutrient, dietary fiber, and alcohol intakes did not differ significantly between the 2 diets, whereas dietary TAC, α-tocopherol, and ascorbic acid were significantly (P <0.001) higher during the HT diet. Plasma α-tocopherol rose during the HT and decreased during the LT diet (P <0.02 for difference) without changes in markers of oxidative stress except plasma malondialdehyde, which decreased unexpectedly during the LT diet (P <0.05). Plasma high-sensitivity C-reactive protein, alanine aminotransferase, gamma-glutamyltranspeptidase, and alkaline phosphatase concentrations decreased during the HT compared with the LT diet (mean ± SEM for pre-post changes: -0.72 ± 0.37 compared with 1.05 ± 0.60 mg/L, P <0.01; -1.73 ± 1.02 compared with 2.33 ± 2.58 U/L, P <0.01; -2.12 ± 1.45 compared with 5.15 ± 2.98 U/L, P <0.05; and 1.36 ± 1.34 compared with 5.06 ± 2.00 U/L, P <0.01, respectively). Conclusion: Selecting foods according to their TAC markedly affects antioxidant intake and modulates hepatic contribution to systemic inflammation without affecting traditional markers of antioxidant status.
AB - Background: It is unknown whether diets with a high dietary total antioxidant capacity (TAC) can modify oxidative stress, low-grade inflammation, or liver dysfunction, all of which are risk factors for type 2 diabetes and cardiovascular disease. Objective: We studied the effect of high- and low-TAC (HT and LT, respectively) diets on markers of antioxidant status, systemic inflammation, and liver dysfunction. Design: In a crossover intervention, 33 healthy adults (19 men, 14 women) received the HT and LT diets for 2 wk each. Dietary habits were checked with a 3-d food record during both diet periods and the washout period. Results: Fruit and vegetable, macronutrient, dietary fiber, and alcohol intakes did not differ significantly between the 2 diets, whereas dietary TAC, α-tocopherol, and ascorbic acid were significantly (P <0.001) higher during the HT diet. Plasma α-tocopherol rose during the HT and decreased during the LT diet (P <0.02 for difference) without changes in markers of oxidative stress except plasma malondialdehyde, which decreased unexpectedly during the LT diet (P <0.05). Plasma high-sensitivity C-reactive protein, alanine aminotransferase, gamma-glutamyltranspeptidase, and alkaline phosphatase concentrations decreased during the HT compared with the LT diet (mean ± SEM for pre-post changes: -0.72 ± 0.37 compared with 1.05 ± 0.60 mg/L, P <0.01; -1.73 ± 1.02 compared with 2.33 ± 2.58 U/L, P <0.01; -2.12 ± 1.45 compared with 5.15 ± 2.98 U/L, P <0.05; and 1.36 ± 1.34 compared with 5.06 ± 2.00 U/L, P <0.01, respectively). Conclusion: Selecting foods according to their TAC markedly affects antioxidant intake and modulates hepatic contribution to systemic inflammation without affecting traditional markers of antioxidant status.
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M3 - Article
C2 - 18469252
AN - SCOPUS:43549116835
VL - 87
SP - 1290
EP - 1297
JO - American Journal of Clinical Nutrition
JF - American Journal of Clinical Nutrition
SN - 0002-9165
IS - 5
ER -