Foodborne botulism: Clinical diagnosis and medical treatment

Davide Lonati, Azzurra Schicchi, Marta Crevani, Eleonora Buscaglia, Giulia Scaravaggi, Francesca Maida, Marco Cirronis, Valeria Margherita Petrolini, Carlo Alessandro Locatelli

Research output: Contribution to journalReview articlepeer-review

Abstract

Botulinum neurotoxins (BoNTs) produced by Clostridia species are the most potent identified natural toxins. Classically, the toxic neurological syndrome is characterized by an (afebrile) acute symmetric descending flaccid paralysis. The most know typical clinical syndrome of botulism refers to the foodborne form. All different forms are characterized by the same symptoms, caused by toxin-induced neuromuscular paralysis. The diagnosis of botulism is essentially clinical, as well as the decision to apply the specific antidotal treatment. The role of the laboratory is mandatory to confirm the clinical suspicion in relation to regulatory agencies, to identify the BoNTs involved and the source of intoxication. The laboratory diagnosis of foodborne botulism is based on the detection of BoNTs in clinical specimens/food samples and the isolation of BoNT from stools. Foodborne botulism intoxication is often underdiagnosed; the initial symptoms can be confused with more common clinical conditions (i.e., stroke, myasthenia gravis, Guillain-Barré syndrome'Miller-Fisher variant, Eaton-Lambert syndrome, tick paralysis and shellfish or tetrodotoxin poisoning). The treatment includes procedures for decontamination, antidote administration and, when required, support of respiratory function; few differences are related to the different way of exposure.

Original languageEnglish
Article number509
JournalToxins
Volume12
Issue number8
DOIs
Publication statusPublished - Aug 2020

Keywords

  • Botulism
  • Diagnosis
  • Food
  • Intoxication
  • Poison Center
  • Poisoning
  • Rehabilitation
  • Toxicity
  • Treatment

ASJC Scopus subject areas

  • Toxicology
  • Health, Toxicology and Mutagenesis

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