Formulation strategies to modulate the topical delivery of anti-inflammatory compounds.

Carmelo Puglia, Luisa Rizza, Alessia Offerta, Franco Gasparri, Valentina Giannini, Francesco Bonina

Research output: Contribution to journalArticle

Abstract

The aim of this study was to assess the ability of some vehicles (emulsion and emulgel), containing hydrogenated lecithin as penetration enhancer, in increasing the percutaneous absorption of the two model compounds dipotassium glycyrrhizinate (DG) and stearyl glycyrrhetinate (SG). Furthermore SG-loaded solid lipid nanoparticles (SLNs) were prepared and the effect of this vehicle on SG permeation profile was evaluated as well. Percutaneous absorption has been studied in vitro, using excised human skin membranes (i.e., stratum corneum epidermis or [SCE]), and in vivo, determining their anti-inflammatory activity. From the results obtained, the use of both penetration enhancers and SLNs resulted in being valid tools to optimize the topical delivery of DG and SG. Soy lecithin guaranteed an increase in the percutaneous absorption of the two activities and a rapid anti-inflammatory effect in in vivo experiments, whereas SLNs produced an interesting delayed and sustained release of SG.

Original languageEnglish
Pages (from-to)341-353
Number of pages13
JournalJournal of Cosmetic Science
Volume64
Issue number5
Publication statusPublished - Sep 2013

ASJC Scopus subject areas

  • Chemistry(all)
  • Dermatology
  • Medicine(all)

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  • Cite this

    Puglia, C., Rizza, L., Offerta, A., Gasparri, F., Giannini, V., & Bonina, F. (2013). Formulation strategies to modulate the topical delivery of anti-inflammatory compounds. Journal of Cosmetic Science, 64(5), 341-353.