Fosfomycin trometamol versus netilmicin in children’s lower urinary tract infections

Nicola Principi, R. Corda, D. Bassetti, L. A. Varese, L. Peratoner

Research output: Contribution to journalArticle

Abstract

Fosfomycin trometamol (FT), an antibiotic active against the common urinary pathogens, may be demonstrated in adequate urine concentrations up to 36-48 h after a single oral dose of 1-2 g. This pharmacokinetic peculiarity seems to indicate that this antibiotic may be used in single doses in the therapy of lower urinary tract infections (UTIs) in infants and children. The efficacy and safety of FT in single oral doses was compared with those of netilmicin (NM), an aminoglycoside antibiotic with a demonstrated efficacy in bolus doses against UTIs, shown in a multicentric study. One hundred and thirty-five children with lower UTI, diagnosed on the basis of fever (

Original languageEnglish
Pages (from-to)41-45
Number of pages5
JournalChemotherapy
Volume36
DOIs
Publication statusPublished - 1990

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Keywords

  • Bolus dose
  • Fosfomycin trometamol
  • Netilmicin
  • Single dose
  • Urinary tract infection

ASJC Scopus subject areas

  • Infectious Diseases
  • Oncology
  • Pharmacology (medical)
  • Drug Discovery
  • Pharmacology

Cite this

Principi, N., Corda, R., Bassetti, D., Varese, L. A., & Peratoner, L. (1990). Fosfomycin trometamol versus netilmicin in children’s lower urinary tract infections. Chemotherapy, 36, 41-45. https://doi.org/10.1159/000238816