Four dually resistant human cytomegalovirus strains from AIDS patients: Single mutations in UL97 and UL54 open reading frames are responsible for ganciclovir- and foscarnet-specific resistance, respectively

F. Baldanti, A. Sarasini, E. Silini, M. Barbi, A. Lazzarin, K. K. Biron, G. Gerna

Research output: Contribution to journalArticle

Abstract

Four human cytomegalovirus strains with double resistance to both ganciclovir and foscarnet were recovered from acquired immunodeficiency syndrome (AIDS) patients. The four isolates were genetically unrelated and each of them consisted of a single viral population. In addition, for each isolate, UL97 and UL54 open reading frames sequencing showed a single aminoacid change in a conserved domain of each of the two genes.

Original languageEnglish
Pages (from-to)103-104
Number of pages2
JournalScandinavian Journal of Infectious Diseases, Supplement
Issue number99
Publication statusPublished - 1996

ASJC Scopus subject areas

  • Immunology
  • Microbiology (medical)

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